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Abstract

Purpose

To investigate, visualize and quantify the physiology of the human placenta in several dimensions ‐ functional, temporal over gestation, and spatial over the whole organ.
Methods

Bespoke MRI techniques, combining a rich diffusion protocol, anatomical data and T2* mapping together with a multi‐modal pipeline including motion correction and extracted quantitative features were developed and employed on pregnant women between 22 and 38 weeks gestational age including two pregnancies diagnosed with pre‐eclampsia.
Results

A multi‐faceted assessment was demonstrated showing trends of increasing lacunarity, and decreasing T2* and diffusivity over gestation.
Conclusions

The obtained multi‐modal acquisition and quantification shows promising opportunities for studying evolution, adaptation and compensation processes.
Original languageEnglish
Pages (from-to)1191-1204
JournalMagnetic Resonance in Medicine
Volume81
Issue number2
Early online date21 Sept 2018
DOIs
Publication statusPublished - 28 Feb 2019

Keywords

  • Placenta
  • MRI
  • multi-modal

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