Multiphoton luminescence imaging of chemically functionalized multi-walled carbon nanotubes in cells and solid tumors

N Rubio; L M Hirvonen; E Z Chong; J T W Wang; M Bourgognon; H Kafa; H A F M Hassan; W T Al-Jamal; D McCarthy; C Hogstrand; F Festy; K T Al-Jamal

doi:10.1039/c5cc02675j

Multiphoton luminescence imaging of chemically functionalized multi-walled carbon nanotubes in cells and solid tumors

N Rubio, L M Hirvonen, E Z Chong, J T W Wang, M Bourgognon, H Kafa, H A F M Hassan, W T Al-Jamal, D McCarthy, C Hogstrand, F Festy, K T Al-Jamal

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Abstract

The intrinsic nonlinear photoluminescence (PL) property of chemically functionalized multi-walled nanotubes MWNTs (f-MWNTs) is reported in this study. f-MWNTs are imaged in fixed lung epithelial cancer cells (A549) and Kupffer cells in vitro, and in subcutaneously implanted solid tumors in vivo, for the first time, using multiphoton PL and fluorescence lifetime imaging (FLIM). Multiphoton imaging in the near-infrared excitation region (∼750-950 nm), employed in this study in a label-free manner, provides sensitivity and resolution optimal to track f-MWNTs within intra-cellular compartments and facilitates tumour imaging and sentinel lymph node tracking in vivo. Wider applications include employing this technique in live imaging of f-MWNTs in biological milieu to facilitate image-guided drug delivery.

Original language	English
Pages (from-to)	9366-9369
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	51
Issue number	45
DOIs	https://doi.org/10.1039/c5cc02675j
Publication status	Published - 7 Jun 2015

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10.1039/c5cc02675jLicence: CC BY

Rubio Chem Comm 2015Final published version, 2.46 MBLicence: CC BY

18 Citations
1 Article

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration
Taylor, K. M., Muraina, I. A., Brethour, D., Schmitt-Ulms, G., Nimmanon, T., Ziliotto, S., Kille, P. & Hogstrand, C., 7 Jun 2016, (E-pub ahead of print) In: Biochemical Journal. 21 p., BCJ20160388.
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Rubio, N., Hirvonen, L. M., Chong, E. Z., Wang, J. T. W., Bourgognon, M., Kafa, H., Hassan, H. A. F. M., Al-Jamal, W. T., McCarthy, D., Hogstrand, C., Festy, F., & Al-Jamal, K. T. (2015). Multiphoton luminescence imaging of chemically functionalized multi-walled carbon nanotubes in cells and solid tumors. Chemical communications (Cambridge, England), 51(45), 9366-9369. https://doi.org/10.1039/c5cc02675j

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title = "Multiphoton luminescence imaging of chemically functionalized multi-walled carbon nanotubes in cells and solid tumors",

abstract = "The intrinsic nonlinear photoluminescence (PL) property of chemically functionalized multi-walled nanotubes MWNTs (f-MWNTs) is reported in this study. f-MWNTs are imaged in fixed lung epithelial cancer cells (A549) and Kupffer cells in vitro, and in subcutaneously implanted solid tumors in vivo, for the first time, using multiphoton PL and fluorescence lifetime imaging (FLIM). Multiphoton imaging in the near-infrared excitation region (∼750-950 nm), employed in this study in a label-free manner, provides sensitivity and resolution optimal to track f-MWNTs within intra-cellular compartments and facilitates tumour imaging and sentinel lymph node tracking in vivo. Wider applications include employing this technique in live imaging of f-MWNTs in biological milieu to facilitate image-guided drug delivery.",

author = "N Rubio and Hirvonen, {L M} and Chong, {E Z} and Wang, {J T W} and M Bourgognon and H Kafa and Hassan, {H A F M} and Al-Jamal, {W T} and D McCarthy and C Hogstrand and F Festy and Al-Jamal, {K T}",

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Rubio, N, Hirvonen, LM , Chong, EZ , Wang, JTW , Bourgognon, M , Kafa, H , Hassan, HAFM , Al-Jamal, WT, McCarthy, D, Hogstrand, C, Festy, F & Al-Jamal, KT 2015, 'Multiphoton luminescence imaging of chemically functionalized multi-walled carbon nanotubes in cells and solid tumors', Chemical communications (Cambridge, England), vol. 51, no. 45, pp. 9366-9369. https://doi.org/10.1039/c5cc02675j

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T1 - Multiphoton luminescence imaging of chemically functionalized multi-walled carbon nanotubes in cells and solid tumors

AU - Rubio, N

AU - Hirvonen, L M

AU - Chong, E Z

AU - Wang, J T W

AU - Bourgognon, M

AU - Kafa, H

AU - Hassan, H A F M

AU - Al-Jamal, W T

AU - McCarthy, D

AU - Hogstrand, C

AU - Festy, F

AU - Al-Jamal, K T

PY - 2015/6/7

Y1 - 2015/6/7

N2 - The intrinsic nonlinear photoluminescence (PL) property of chemically functionalized multi-walled nanotubes MWNTs (f-MWNTs) is reported in this study. f-MWNTs are imaged in fixed lung epithelial cancer cells (A549) and Kupffer cells in vitro, and in subcutaneously implanted solid tumors in vivo, for the first time, using multiphoton PL and fluorescence lifetime imaging (FLIM). Multiphoton imaging in the near-infrared excitation region (∼750-950 nm), employed in this study in a label-free manner, provides sensitivity and resolution optimal to track f-MWNTs within intra-cellular compartments and facilitates tumour imaging and sentinel lymph node tracking in vivo. Wider applications include employing this technique in live imaging of f-MWNTs in biological milieu to facilitate image-guided drug delivery.

AB - The intrinsic nonlinear photoluminescence (PL) property of chemically functionalized multi-walled nanotubes MWNTs (f-MWNTs) is reported in this study. f-MWNTs are imaged in fixed lung epithelial cancer cells (A549) and Kupffer cells in vitro, and in subcutaneously implanted solid tumors in vivo, for the first time, using multiphoton PL and fluorescence lifetime imaging (FLIM). Multiphoton imaging in the near-infrared excitation region (∼750-950 nm), employed in this study in a label-free manner, provides sensitivity and resolution optimal to track f-MWNTs within intra-cellular compartments and facilitates tumour imaging and sentinel lymph node tracking in vivo. Wider applications include employing this technique in live imaging of f-MWNTs in biological milieu to facilitate image-guided drug delivery.

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DO - 10.1039/c5cc02675j

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JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

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Multiphoton luminescence imaging of chemically functionalized multi-walled carbon nanotubes in cells and solid tumors

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Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration

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