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Multiphoton luminescence imaging of chemically functionalized multi-walled carbon nanotubes in cells and solid tumors

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)9366-9369
Number of pages4
JournalChemical communications (Cambridge, England)
Volume51
Issue number45
DOIs
Published7 Jun 2015

Documents

  • Rubio Chem Comm 2015

    c5cc02675j.pdf, 2.46 MB, application/pdf

    Uploaded date:07 Jan 2016

    Version:Final published version

    Licence:CC BY

King's Authors

Abstract

The intrinsic nonlinear photoluminescence (PL) property of chemically functionalized multi-walled nanotubes MWNTs (f-MWNTs) is reported in this study. f-MWNTs are imaged in fixed lung epithelial cancer cells (A549) and Kupffer cells in vitro, and in subcutaneously implanted solid tumors in vivo, for the first time, using multiphoton PL and fluorescence lifetime imaging (FLIM). Multiphoton imaging in the near-infrared excitation region (∼750-950 nm), employed in this study in a label-free manner, provides sensitivity and resolution optimal to track f-MWNTs within intra-cellular compartments and facilitates tumour imaging and sentinel lymph node tracking in vivo. Wider applications include employing this technique in live imaging of f-MWNTs in biological milieu to facilitate image-guided drug delivery.

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