Multiple functions of tail-anchor domains of mitochondrial outer membrane proteins

Shukry Habib, Andreja Vasiljev, Walter Neupert, Doron Rapaport

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Tail-anchored proteins form a distinct class of membrane proteins that have a single membrane anchor sequence at their C-terminus, the tail-anchor. Their N-terminal portion is exposed to the cytosol. We have studied the roles of tail-anchor domains of proteins residing in the mitochondrial outer membrane. Four distinct functions of the tail-anchor domain were identified. First, the domain mediates the targeting to mitochondria in a process that probably requires a net positive charge at the C-terminally flanking segment. Second, tail-anchor domains facilitate the insertion into the mitochondrial outer membrane. Third, the tail-anchor is responsible for the assembly of the respective protein into functional multi-subunit complexes; and fourth, tail-anchor domains can stabilize such complexes.
Original languageEnglish
Pages (from-to)511-515
Number of pages5
JournalFEBS Letters
Issue number3
Publication statusPublished - 18 Dec 2003


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  • Membrane Proteins
  • Mitochondrial Proteins
  • Molecular Sequence Data
  • Phenotype
  • Protein Sorting Signals
  • Protein Structure, Tertiary
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  • Saccharomyces cerevisiae

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