Multiscale and multimodal imaging of utero-placental anatomy and function in pregnancy

Vijayalakshmi Srinivasan, Andrew Melbourne, Charlotte Oyston, Joanna L James, Alys R Clark

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Placental structures at the nano-, micro-, and macro scale each play important roles in contributing to its function. As such, quantifying the dynamic way in which placental structure evolves during pregnancy is critical to both clinical diagnosis of pregnancy disorders, and mechanistic understanding of their pathophysiology. Imaging the placenta, both exvivo and invivo, can provide a wealth of structural and/or functional information. This review outlines how imaging across modalities and spatial scales can ultimately come together to improve our understanding of normal and pathological pregnancies. We discuss how imaging technologies are evolving to provide new insights into placental physiology across disciplines, and how advanced computational algorithms can be used alongside state-of-the-art imaging to obtain a holistic view of placental structure and its associated functions to improve our understanding of placental function in health and disease.

Original languageEnglish
Pages (from-to)111-122
Number of pages12
JournalPlacenta
Volume112
Early online date23 Jul 2021
DOIs
Publication statusPublished - 1 Sept 2021

Keywords

  • Placenta
  • Imaging
  • MRI
  • Doppler ultrasound
  • Micro-CT
  • Pregnancy

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