Multiscale characterization of cortical signatures in positive and negative schizotypy: A worldwide ENIGMA study

M. Kirschner; B. Hodzic-Santor; L. Kennedy; J. Y. Hansen; M. Antoniades; I. Nenadic; T. Kircher; A. Krug; T. Meller; U. Dannlowski; D. Grotegerd; K. Flinkenfluegel; S. Meinert; T. Borgers; J. Goltermann; T. Hahn; J. Boehnlein; E. J. Leehr; C. Barkhau; A. Fornito; A. Arnatkeviciute; M. Bellgrove; J. Tiego; P. DeRosse; M. Green; Y. Quide; C. Pantelis; R. C. K. Chan; Y. Wang; U. Ettinger; M. Debbane; M. Derome; C. Gaser; B. Besteher; K. Diederen; T. J. Spencer; J. Houenou; E. Pomarol-Clotet; R. Salvador; W. Roessler; L. Smigielski; V. Kumari; P Premkumar; Matthias Kirschner

doi:10.1101/2024.05.03.24306736

Multiscale characterization of cortical signatures in positive and negative schizotypy: A worldwide ENIGMA study

M. Kirschner, B. Hodzic-Santor, L. Kennedy, J. Y. Hansen, M. Antoniades, I. Nenadic, T. Kircher, A. Krug, T. Meller, U. Dannlowski, D. Grotegerd, K. Flinkenfluegel, S. Meinert, T. Borgers, J. Goltermann, T. Hahn, J. Boehnlein, E. J. Leehr, C. Barkhau, A. FornitoA. Arnatkeviciute, M. Bellgrove, J. Tiego, P. DeRosse, M. Green, Y. Quide, C. Pantelis, R. C. K. Chan, Y. Wang, U. Ettinger, M. Debbane, M. Derome, C. Gaser, B. Besteher, K. Diederen, T. J. Spencer, J. Houenou, E. Pomarol-Clotet, R. Salvador, W. Roessler, L. Smigielski, V. Kumari, P Premkumar, Matthias Kirschner^*

^*Corresponding author for this work

Research output: Working paper/Preprint › Preprint

Abstract

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these schizotypy dimensions is lacking. Leveraging 3D brain MRI data from 2,730 unmedicated healthy individuals, we identified neuroanatomical profiles of positive and negative schizotypy and systematically compared them to disorder-specific, micro-architectural, connectome, and neurotransmitter-level measures. Positive and negative schizotypy were associated with thinner frontal and thicker paralimbic cortical areas, respectively, and were differentially linked to cortical patterns of schizophrenia-spectrum and neurodevelopmental conditions. Furthermore, these schizotypal cortical patterns mapped onto local attributes of gene expression, cortical myelination, D1 and histamine receptor distributions. Network models identified cortical hub vulnerability to schizotypy-related thickness reduction and epicenters in sensorimotor-to-association and paralimbic areas. This study yields insights into the complex cortical signatures of schizotypy and their relationship to diverse features of cortical organization.

Original language	Undefined/Unknown
DOIs	https://doi.org/10.1101/2024.05.03.24306736
Publication status	Published - 2024

Keywords

psychiatry and clinical psychology

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Cite this

Kirschner, M., Hodzic-Santor, B., Kennedy, L., Hansen, J. Y., Antoniades, M., Nenadic, I., Kircher, T., Krug, A., Meller, T., Dannlowski, U., Grotegerd, D., Flinkenfluegel, K., Meinert, S., Borgers, T., Goltermann, J., Hahn, T., Boehnlein, J., Leehr, E. J., Barkhau, C., ... Kirschner, M. (2024). Multiscale characterization of cortical signatures in positive and negative schizotypy: A worldwide ENIGMA study. https://doi.org/10.1101/2024.05.03.24306736

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abstract = "Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these schizotypy dimensions is lacking. Leveraging 3D brain MRI data from 2,730 unmedicated healthy individuals, we identified neuroanatomical profiles of positive and negative schizotypy and systematically compared them to disorder-specific, micro-architectural, connectome, and neurotransmitter-level measures. Positive and negative schizotypy were associated with thinner frontal and thicker paralimbic cortical areas, respectively, and were differentially linked to cortical patterns of schizophrenia-spectrum and neurodevelopmental conditions. Furthermore, these schizotypal cortical patterns mapped onto local attributes of gene expression, cortical myelination, D1 and histamine receptor distributions. Network models identified cortical hub vulnerability to schizotypy-related thickness reduction and epicenters in sensorimotor-to-association and paralimbic areas. This study yields insights into the complex cortical signatures of schizotypy and their relationship to diverse features of cortical organization.",

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author = "M. Kirschner and B. Hodzic-Santor and L. Kennedy and Hansen, {J. Y.} and M. Antoniades and I. Nenadic and T. Kircher and A. Krug and T. Meller and U. Dannlowski and D. Grotegerd and K. Flinkenfluegel and S. Meinert and T. Borgers and J. Goltermann and T. Hahn and J. Boehnlein and Leehr, {E. J.} and C. Barkhau and A. Fornito and A. Arnatkeviciute and M. Bellgrove and J. Tiego and P. DeRosse and M. Green and Y. Quide and C. Pantelis and Chan, {R. C. K.} and Y. Wang and U. Ettinger and M. Debbane and M. Derome and C. Gaser and B. Besteher and K. Diederen and Spencer, {T. J.} and J. Houenou and E. Pomarol-Clotet and R. Salvador and W. Roessler and L. Smigielski and V. Kumari and P Premkumar and Matthias Kirschner",

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Kirschner, M, Hodzic-Santor, B, Kennedy, L, Hansen, JY, Antoniades, M, Nenadic, I, Kircher, T, Krug, A, Meller, T, Dannlowski, U, Grotegerd, D, Flinkenfluegel, K, Meinert, S, Borgers, T, Goltermann, J, Hahn, T, Boehnlein, J, Leehr, EJ, Barkhau, C, Fornito, A, Arnatkeviciute, A, Bellgrove, M, Tiego, J, DeRosse, P, Green, M, Quide, Y, Pantelis, C, Chan, RCK, Wang, Y, Ettinger, U, Debbane, M, Derome, M, Gaser, C, Besteher, B, Diederen, K , Spencer, TJ, Houenou, J, Pomarol-Clotet, E, Salvador, R, Roessler, W, Smigielski, L, Kumari, V , Premkumar, P & Kirschner, M 2024 'Multiscale characterization of cortical signatures in positive and negative schizotypy: A worldwide ENIGMA study'. https://doi.org/10.1101/2024.05.03.24306736

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T1 - Multiscale characterization of cortical signatures in positive and negative schizotypy: A worldwide ENIGMA study

AU - Kirschner, M.

AU - Hodzic-Santor, B.

AU - Kennedy, L.

AU - Hansen, J. Y.

AU - Antoniades, M.

AU - Nenadic, I.

AU - Kircher, T.

AU - Krug, A.

AU - Meller, T.

AU - Dannlowski, U.

AU - Grotegerd, D.

AU - Flinkenfluegel, K.

AU - Meinert, S.

AU - Borgers, T.

AU - Goltermann, J.

AU - Hahn, T.

AU - Boehnlein, J.

AU - Leehr, E. J.

AU - Barkhau, C.

AU - Fornito, A.

AU - Arnatkeviciute, A.

AU - Bellgrove, M.

AU - Tiego, J.

AU - DeRosse, P.

AU - Green, M.

AU - Quide, Y.

AU - Pantelis, C.

AU - Chan, R. C. K.

AU - Wang, Y.

AU - Ettinger, U.

AU - Debbane, M.

AU - Derome, M.

AU - Gaser, C.

AU - Besteher, B.

AU - Diederen, K.

AU - Spencer, T. J.

AU - Houenou, J.

AU - Pomarol-Clotet, E.

AU - Salvador, R.

AU - Roessler, W.

AU - Smigielski, L.

AU - Kumari, V.

AU - Premkumar, P

AU - Kirschner, Matthias

PY - 2024

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N2 - Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these schizotypy dimensions is lacking. Leveraging 3D brain MRI data from 2,730 unmedicated healthy individuals, we identified neuroanatomical profiles of positive and negative schizotypy and systematically compared them to disorder-specific, micro-architectural, connectome, and neurotransmitter-level measures. Positive and negative schizotypy were associated with thinner frontal and thicker paralimbic cortical areas, respectively, and were differentially linked to cortical patterns of schizophrenia-spectrum and neurodevelopmental conditions. Furthermore, these schizotypal cortical patterns mapped onto local attributes of gene expression, cortical myelination, D1 and histamine receptor distributions. Network models identified cortical hub vulnerability to schizotypy-related thickness reduction and epicenters in sensorimotor-to-association and paralimbic areas. This study yields insights into the complex cortical signatures of schizotypy and their relationship to diverse features of cortical organization.

AB - Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these schizotypy dimensions is lacking. Leveraging 3D brain MRI data from 2,730 unmedicated healthy individuals, we identified neuroanatomical profiles of positive and negative schizotypy and systematically compared them to disorder-specific, micro-architectural, connectome, and neurotransmitter-level measures. Positive and negative schizotypy were associated with thinner frontal and thicker paralimbic cortical areas, respectively, and were differentially linked to cortical patterns of schizophrenia-spectrum and neurodevelopmental conditions. Furthermore, these schizotypal cortical patterns mapped onto local attributes of gene expression, cortical myelination, D1 and histamine receptor distributions. Network models identified cortical hub vulnerability to schizotypy-related thickness reduction and epicenters in sensorimotor-to-association and paralimbic areas. This study yields insights into the complex cortical signatures of schizotypy and their relationship to diverse features of cortical organization.

KW - psychiatry and clinical psychology

U2 - 10.1101/2024.05.03.24306736

DO - 10.1101/2024.05.03.24306736

M3 - Preprint

BT - Multiscale characterization of cortical signatures in positive and negative schizotypy: A worldwide ENIGMA study

ER -