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Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network

Research output: Contribution to journalArticle

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Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network. / Xiao, Nan; Humphrey, Jay D.; Figueroa, C. Alberto.

In: JOURNAL OF COMPUTATIONAL PHYSICS, Vol. 244, 01.07.2013, p. 22-40.

Research output: Contribution to journalArticle

Harvard

Xiao, N, Humphrey, JD & Figueroa, CA 2013, 'Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network', JOURNAL OF COMPUTATIONAL PHYSICS, vol. 244, pp. 22-40. https://doi.org/10.1016/j.jcp.2012.09.016

APA

Xiao, N., Humphrey, J. D., & Figueroa, C. A. (2013). Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network. JOURNAL OF COMPUTATIONAL PHYSICS, 244, 22-40. https://doi.org/10.1016/j.jcp.2012.09.016

Vancouver

Xiao N, Humphrey JD, Figueroa CA. Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network. JOURNAL OF COMPUTATIONAL PHYSICS. 2013 Jul 1;244:22-40. https://doi.org/10.1016/j.jcp.2012.09.016

Author

Xiao, Nan ; Humphrey, Jay D. ; Figueroa, C. Alberto. / Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network. In: JOURNAL OF COMPUTATIONAL PHYSICS. 2013 ; Vol. 244. pp. 22-40.

Bibtex Download

@article{04b7adcf450e4f808ed48690944a57b7,
title = "Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network",
abstract = "In this article, we present a computational multi-scale model of fully three-dimensional and unsteady hemodynamics within the primary large arteries in the human. Computed tomography image data from two different patients were used to reconstruct a nearly complete network of the major arteries from head to foot. A linearized coupled-momentum method for fluid–structure-interaction was used to describe vessel wall deformability and a multi-domain method for outflow boundary condition specification was used to account for the distal circulation. We demonstrated that physiologically realistic results can be obtained from the model by comparing simulated quantities such as regional blood flow, pressure and flow waveforms, and pulse wave velocities to known values in the literature. We also simulated the impact of age-related arterial stiffening on wave propagation phenomena by progressively increasing the stiffness of the central arteries and found that the predicted effects on pressure amplification and pulse wave velocity are in agreement with findings in the clinical literature. This work demonstrates the feasibility of three-dimensional techniques for simulating hemodynamics in a full-body compliant arterial network.",
keywords = "Fluid-structure interaction, COLLABORATIVE TRIAL ACCT, COMPUTER-SIMULATION, TREE, PULSE-WAVE VELOCITY, FLUID-STRUCTURE INTERACTION, Hemodynamics, Multiscale modeling, Arterial stiffening, Wave propagation, Full-body arterial model, STIFFNESS, Pulse wave velocity, HYPERTENSION, ONE-DIMENSIONAL MODEL, BLOOD-FLOW, PRESSURE, Hypertension",
author = "Nan Xiao and Humphrey, {Jay D.} and Figueroa, {C. Alberto}",
year = "2013",
month = "7",
day = "1",
doi = "10.1016/j.jcp.2012.09.016",
language = "English",
volume = "244",
pages = "22--40",
journal = "JOURNAL OF COMPUTATIONAL PHYSICS",
issn = "0021-9991",
publisher = "ACADEMIC PRESS INC",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network

AU - Xiao, Nan

AU - Humphrey, Jay D.

AU - Figueroa, C. Alberto

PY - 2013/7/1

Y1 - 2013/7/1

N2 - In this article, we present a computational multi-scale model of fully three-dimensional and unsteady hemodynamics within the primary large arteries in the human. Computed tomography image data from two different patients were used to reconstruct a nearly complete network of the major arteries from head to foot. A linearized coupled-momentum method for fluid–structure-interaction was used to describe vessel wall deformability and a multi-domain method for outflow boundary condition specification was used to account for the distal circulation. We demonstrated that physiologically realistic results can be obtained from the model by comparing simulated quantities such as regional blood flow, pressure and flow waveforms, and pulse wave velocities to known values in the literature. We also simulated the impact of age-related arterial stiffening on wave propagation phenomena by progressively increasing the stiffness of the central arteries and found that the predicted effects on pressure amplification and pulse wave velocity are in agreement with findings in the clinical literature. This work demonstrates the feasibility of three-dimensional techniques for simulating hemodynamics in a full-body compliant arterial network.

AB - In this article, we present a computational multi-scale model of fully three-dimensional and unsteady hemodynamics within the primary large arteries in the human. Computed tomography image data from two different patients were used to reconstruct a nearly complete network of the major arteries from head to foot. A linearized coupled-momentum method for fluid–structure-interaction was used to describe vessel wall deformability and a multi-domain method for outflow boundary condition specification was used to account for the distal circulation. We demonstrated that physiologically realistic results can be obtained from the model by comparing simulated quantities such as regional blood flow, pressure and flow waveforms, and pulse wave velocities to known values in the literature. We also simulated the impact of age-related arterial stiffening on wave propagation phenomena by progressively increasing the stiffness of the central arteries and found that the predicted effects on pressure amplification and pulse wave velocity are in agreement with findings in the clinical literature. This work demonstrates the feasibility of three-dimensional techniques for simulating hemodynamics in a full-body compliant arterial network.

KW - Fluid-structure interaction

KW - COLLABORATIVE TRIAL ACCT

KW - COMPUTER-SIMULATION

KW - TREE

KW - PULSE-WAVE VELOCITY

KW - FLUID-STRUCTURE INTERACTION

KW - Hemodynamics

KW - Multiscale modeling

KW - Arterial stiffening

KW - Wave propagation

KW - Full-body arterial model

KW - STIFFNESS

KW - Pulse wave velocity

KW - HYPERTENSION

KW - ONE-DIMENSIONAL MODEL

KW - BLOOD-FLOW

KW - PRESSURE

KW - Hypertension

U2 - 10.1016/j.jcp.2012.09.016

DO - 10.1016/j.jcp.2012.09.016

M3 - Article

VL - 244

SP - 22

EP - 40

JO - JOURNAL OF COMPUTATIONAL PHYSICS

JF - JOURNAL OF COMPUTATIONAL PHYSICS

SN - 0021-9991

ER -

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