Murine models of inflammation: role of CD23

Y Riffo-Vasquez; S Pitchford; D Spina

doi:10.1034/j.1398-9995.2000.00503.x

Murine models of inflammation: role of CD23

Y Riffo-Vasquez, S Pitchford, D Spina

Institute of Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The role of IgE in eosinophil recruitment and bronchial hyperresponsiveness has been extensively studied with murine models of inflammation. Many investigators using various knockout models have clearly shown that both IgE-dependent and -independent pathways play a role in eosinophil recruitment and bronchial hyperresponsiveness after allergen challenge, illustrating the complexity of airways inflammation. The expression of this response is likely to involve many interacting pathways, and it will be a considerable challenge to determine key points within these pathways that will yield novel targets for future therapeutic strategies.

Original language	English
Pages (from-to)	21-6
Number of pages	6
Journal	Allergy
Volume	55
Issue number	61
DOIs	https://doi.org/10.1034/j.1398-9995.2000.00503.x
Publication status	Published - 2000

Keywords

Animals
Bronchial Hyperreactivity
Disease Models, Animal
Eosinophils
Immunoglobulin E
Inflammation
Lung
Mice
Receptors, IgE

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10.1034/j.1398-9995.2000.00503.x

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abstract = "The role of IgE in eosinophil recruitment and bronchial hyperresponsiveness has been extensively studied with murine models of inflammation. Many investigators using various knockout models have clearly shown that both IgE-dependent and -independent pathways play a role in eosinophil recruitment and bronchial hyperresponsiveness after allergen challenge, illustrating the complexity of airways inflammation. The expression of this response is likely to involve many interacting pathways, and it will be a considerable challenge to determine key points within these pathways that will yield novel targets for future therapeutic strategies.",

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AU - Pitchford, S

AU - Spina, D

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N2 - The role of IgE in eosinophil recruitment and bronchial hyperresponsiveness has been extensively studied with murine models of inflammation. Many investigators using various knockout models have clearly shown that both IgE-dependent and -independent pathways play a role in eosinophil recruitment and bronchial hyperresponsiveness after allergen challenge, illustrating the complexity of airways inflammation. The expression of this response is likely to involve many interacting pathways, and it will be a considerable challenge to determine key points within these pathways that will yield novel targets for future therapeutic strategies.

AB - The role of IgE in eosinophil recruitment and bronchial hyperresponsiveness has been extensively studied with murine models of inflammation. Many investigators using various knockout models have clearly shown that both IgE-dependent and -independent pathways play a role in eosinophil recruitment and bronchial hyperresponsiveness after allergen challenge, illustrating the complexity of airways inflammation. The expression of this response is likely to involve many interacting pathways, and it will be a considerable challenge to determine key points within these pathways that will yield novel targets for future therapeutic strategies.

KW - Animals

KW - Bronchial Hyperreactivity

KW - Disease Models, Animal

KW - Eosinophils

KW - Immunoglobulin E

KW - Inflammation

KW - Lung

KW - Mice

KW - Receptors, IgE

UR - http://www.scopus.com/inward/record.url?scp=0033932562&partnerID=8YFLogxK

U2 - 10.1034/j.1398-9995.2000.00503.x

DO - 10.1034/j.1398-9995.2000.00503.x

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VL - 55

SP - 21

EP - 26

JO - Allergy

JF - Allergy

IS - 61

ER -

Murine models of inflammation: role of CD23

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Keywords

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