Mutation analysis of VCP in British familial and sporadic amyotrophic lateral sclerosis patients

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Abstract

Mutations in the valosin-containing-protein (VCP) gene are associated with the multidisorder disease, inclusion body myopathy with Pagets and associated frontotemporal dementia. This disease is characterized pathologically by large ubiquitinated, TAR DNA Binding Protein 43 (TDP-43) positive inclusions. These inclusions are also a common feature in neurological diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTLD). Mutations in the VCP gene have been identified in ALS patients, therefore we aimed to characterize VCP variations in our own cohort of familial and sporadic ALS patients by sequencing all 17 coding exons of VCP. This study failed to detect any exonic variations in a subset of British familial and sporadic ALS patients. (C) 2012 Elsevier Inc. All rights reserved.

Original languageEnglish
Article number2721.e1
Pages (from-to)-
Number of pages2
JournalNeurobiology of Aging
Volume33
Issue number11
DOIs
Publication statusPublished - Nov 2012

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