Myelin Water Fraction Changes in Febrile Seizures

Krisztina Moldovan, Jerrold L. Boxerman, Jonathan O’Muircheartaigh, Doug Dean, Stephanie Eyerly-Webb, G. Rees Cosgrove, Frank Pucci, Sean C.L. Deoni, Heather S. Spader

Research output: Contribution to journalArticlepeer-review

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Abstract

Objective The objective of this feasibility study was to investigate whether myelin water fraction (MWF) patterns can differentiate children presenting with febrile seizures who will go on to develop nonfebrile epilepsy from those who will not. Patients and Methods As part of a prospective study of myelination patterns in pediatric epilepsy, seven subjects with febrile seizures underwent magnetic resonance imaging (MRI) including the following standard sequences—T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR)—and an additional experimental sequence, multicomponent-derived equilibrium single-pulse observation of T1 and T2 (mcDESPOT) to quantify MWF. For each of these subjects, MWF maps were derived and compared with an age-matched population-averaged MWF atlas. Results All seven subjects (
Original languageEnglish
Pages (from-to)61-67
JournalClinical Neurology and Neurosurgery
Volume175
Early online date10 Oct 2018
DOIs
Publication statusE-pub ahead of print - 10 Oct 2018

Keywords

  • myelin
  • epilepsy
  • febrile
  • pediatrics

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