Myosin 10 is involved in murine pigmentation

Kifayathullah Liakath-Ali; Valerie E. Vancollie; Inês Sequeira; Christopher J. Lelliott; Fiona M. Watt

doi:10.1111/exd.13528

Myosin 10 is involved in murine pigmentation

Kifayathullah Liakath-Ali, Valerie E. Vancollie, Inês Sequeira, Christopher J. Lelliott, Fiona M. Watt^*

^*Corresponding author for this work

Wellcome Sanger Institute

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

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Abstract

Myosins are molecular motors that are well known for their role in cell movement and contractile functions. Although extensively studied in muscle physiology, little is known about the function of myosins in mammalian skin. As part of the Sanger Institute Mouse Genetics Project, we have identified a role for Myo10 in pigmentation, with a phenotype unlike those of Myo5a or Myo7a. Adult mice homozygous for a disrupted Myo10 allele on a C57BL/6N background displayed a high degree of penetrance for white patches on their abdomen and dorsal surface. Forepaw syndactyly and hind paw syndactyly were also observed in these mice. Tail epidermal wholemounts showed a complete lack of melanocytes in the hair follicles and interfollicular epidermis. Myo10 has previously been implicated in human pigmentation. Our current study reveals involvement of Myo10 in murine skin pigmentation.

Original language	English
Journal	Experimental Dermatology
Early online date	24 Apr 2018
DOIs	https://doi.org/10.1111/exd.13528
Publication status	E-pub ahead of print - 24 Apr 2018

Keywords

Hair follicles
Melanocytes
Myosin
Pigmentation

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Myosin 10 is involved in_LIAKATH-ALI_Firstonline24April2018_GOLD VoR (CC BY)Final published version, 542 KBLicence: CC BY

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title = "Myosin 10 is involved in murine pigmentation",

abstract = "Myosins are molecular motors that are well known for their role in cell movement and contractile functions. Although extensively studied in muscle physiology, little is known about the function of myosins in mammalian skin. As part of the Sanger Institute Mouse Genetics Project, we have identified a role for Myo10 in pigmentation, with a phenotype unlike those of Myo5a or Myo7a. Adult mice homozygous for a disrupted Myo10 allele on a C57BL/6N background displayed a high degree of penetrance for white patches on their abdomen and dorsal surface. Forepaw syndactyly and hind paw syndactyly were also observed in these mice. Tail epidermal wholemounts showed a complete lack of melanocytes in the hair follicles and interfollicular epidermis. Myo10 has previously been implicated in human pigmentation. Our current study reveals involvement of Myo10 in murine skin pigmentation.",

keywords = "Hair follicles, Melanocytes, Myosin, Pigmentation",

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AU - Liakath-Ali, Kifayathullah

AU - Vancollie, Valerie E.

AU - Sequeira, Inês

AU - Lelliott, Christopher J.

AU - Watt, Fiona M.

PY - 2018/4/24

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N2 - Myosins are molecular motors that are well known for their role in cell movement and contractile functions. Although extensively studied in muscle physiology, little is known about the function of myosins in mammalian skin. As part of the Sanger Institute Mouse Genetics Project, we have identified a role for Myo10 in pigmentation, with a phenotype unlike those of Myo5a or Myo7a. Adult mice homozygous for a disrupted Myo10 allele on a C57BL/6N background displayed a high degree of penetrance for white patches on their abdomen and dorsal surface. Forepaw syndactyly and hind paw syndactyly were also observed in these mice. Tail epidermal wholemounts showed a complete lack of melanocytes in the hair follicles and interfollicular epidermis. Myo10 has previously been implicated in human pigmentation. Our current study reveals involvement of Myo10 in murine skin pigmentation.

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KW - Hair follicles

KW - Melanocytes

KW - Myosin

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Myosin 10 is involved in murine pigmentation

Abstract

Keywords

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