N-methyl-D-aspartate receptor antibody-associated movement disorder without encephalopathy

Yael Hacohen; Nomazulu  Dlamini; Tamasine Hedderly; Elaine Hughes; Martin Woods; Angela Vincent; Ming Lim

doi:10.1111/dmcn.12321

N-methyl-D-aspartate receptor antibody-associated movement disorder without encephalopathy

Yael Hacohen, Nomazulu Dlamini, Tamasine Hedderly, Elaine Hughes, Martin Woods, Angela Vincent, Ming Lim^*

^*Corresponding author for this work

Guys & St Thomas NHS Fdn Trust, Guy's & St Thomas' NHS Foundation Trust, King's Health Partners, Evelina Childrens Hosp, Kings Hlth Partners Acad Hlth Sci Ctr
University of Oxford

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is a well-recognized clinico-immunological syndrome that presents with a movement disorder, cognitive decline, psychiatric symptoms, and epileptic seizures. A pure monosymptomatic presentation is rare; however, some patients present predominantly with a movement disorder in the absence of encephalopathy. Here, we describe three paediatric patients with an NMDAR antibody-mediated movement disorder: a 5-year-old female with acute onset hemichorea, a 10-year-old female with generalized chorea, and a 12-year-old male with abdominal myoclonus. These patients did not develop the characteristic encephalopathy syndrome seen in NMDAR encephalitis, but all three had other associated subtle cognitive deficits. The patients demonstrated good responses to immunotherapy.

Original language	English
Pages (from-to)	190-193
Number of pages	4
Journal	Developmental Medicine and Child Neurology
Volume	56
Issue number	2
DOIs	https://doi.org/10.1111/dmcn.12321
Publication status	Published - Feb 2014

Keywords

NMDA RECEPTOR
NEURONAL SURFACE
ENCEPHALITIS
CHILDREN
BINDING
PANDAS
CHOREA
LUPUS

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title = "N-methyl-D-aspartate receptor antibody-associated movement disorder without encephalopathy",

abstract = "N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is a well-recognized clinico-immunological syndrome that presents with a movement disorder, cognitive decline, psychiatric symptoms, and epileptic seizures. A pure monosymptomatic presentation is rare; however, some patients present predominantly with a movement disorder in the absence of encephalopathy. Here, we describe three paediatric patients with an NMDAR antibody-mediated movement disorder: a 5-year-old female with acute onset hemichorea, a 10-year-old female with generalized chorea, and a 12-year-old male with abdominal myoclonus. These patients did not develop the characteristic encephalopathy syndrome seen in NMDAR encephalitis, but all three had other associated subtle cognitive deficits. The patients demonstrated good responses to immunotherapy.",

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AU - Hacohen, Yael

AU - Dlamini, Nomazulu

AU - Hedderly, Tamasine

AU - Hughes, Elaine

AU - Woods, Martin

AU - Vincent, Angela

AU - Lim, Ming

PY - 2014/2

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AB - N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is a well-recognized clinico-immunological syndrome that presents with a movement disorder, cognitive decline, psychiatric symptoms, and epileptic seizures. A pure monosymptomatic presentation is rare; however, some patients present predominantly with a movement disorder in the absence of encephalopathy. Here, we describe three paediatric patients with an NMDAR antibody-mediated movement disorder: a 5-year-old female with acute onset hemichorea, a 10-year-old female with generalized chorea, and a 12-year-old male with abdominal myoclonus. These patients did not develop the characteristic encephalopathy syndrome seen in NMDAR encephalitis, but all three had other associated subtle cognitive deficits. The patients demonstrated good responses to immunotherapy.

KW - NMDA RECEPTOR

KW - NEURONAL SURFACE

KW - ENCEPHALITIS

KW - CHILDREN

KW - BINDING

KW - PANDAS

KW - CHOREA

KW - LUPUS

U2 - 10.1111/dmcn.12321

DO - 10.1111/dmcn.12321

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JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

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ER -

N-methyl-D-aspartate receptor antibody-associated movement disorder without encephalopathy

Abstract

Keywords

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