N-methyl-D-aspartate receptor antibody-associated movement disorder without encephalopathy

Yael Hacohen, Nomazulu Dlamini, Tamasine Hedderly, Elaine Hughes, Martin Woods, Angela Vincent, Ming Lim*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    31 Citations (Scopus)

    Abstract

    N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is a well-recognized clinico-immunological syndrome that presents with a movement disorder, cognitive decline, psychiatric symptoms, and epileptic seizures. A pure monosymptomatic presentation is rare; however, some patients present predominantly with a movement disorder in the absence of encephalopathy. Here, we describe three paediatric patients with an NMDAR antibody-mediated movement disorder: a 5-year-old female with acute onset hemichorea, a 10-year-old female with generalized chorea, and a 12-year-old male with abdominal myoclonus. These patients did not develop the characteristic encephalopathy syndrome seen in NMDAR encephalitis, but all three had other associated subtle cognitive deficits. The patients demonstrated good responses to immunotherapy.

    Original languageEnglish
    Pages (from-to)190-193
    Number of pages4
    JournalDevelopmental Medicine and Child Neurology
    Volume56
    Issue number2
    DOIs
    Publication statusPublished - Feb 2014

    Keywords

    • NMDA RECEPTOR
    • NEURONAL SURFACE
    • ENCEPHALITIS
    • CHILDREN
    • BINDING
    • PANDAS
    • CHOREA
    • LUPUS

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