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N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: A study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects

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N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia : A study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects. / Premkumar, Preethi; Parbhakar, Vivek A.; Fannon, Dominic; Lythgoe, David; Williams, Steven; Kuipers, Elizabeth; Kumari, Veena.

In: Psychiatry Research. Neuroimaging, Vol. 182, No. 3, 30.06.2010, p. 251 - 260.

Research output: Contribution to journalArticle

Harvard

Premkumar, P, Parbhakar, VA, Fannon, D, Lythgoe, D, Williams, S, Kuipers, E & Kumari, V 2010, 'N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: A study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects', Psychiatry Research. Neuroimaging, vol. 182, no. 3, pp. 251 - 260. https://doi.org/10.1016/j.pscychresns.2010.02.008

APA

Premkumar, P., Parbhakar, V. A., Fannon, D., Lythgoe, D., Williams, S., Kuipers, E., & Kumari, V. (2010). N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: A study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects. Psychiatry Research. Neuroimaging, 182(3), 251 - 260. https://doi.org/10.1016/j.pscychresns.2010.02.008

Vancouver

Premkumar P, Parbhakar VA, Fannon D, Lythgoe D, Williams S, Kuipers E et al. N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: A study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects. Psychiatry Research. Neuroimaging. 2010 Jun 30;182(3):251 - 260. https://doi.org/10.1016/j.pscychresns.2010.02.008

Author

Premkumar, Preethi ; Parbhakar, Vivek A. ; Fannon, Dominic ; Lythgoe, David ; Williams, Steven ; Kuipers, Elizabeth ; Kumari, Veena. / N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia : A study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects. In: Psychiatry Research. Neuroimaging. 2010 ; Vol. 182, No. 3. pp. 251 - 260.

Bibtex Download

@article{03551d6ef4c14a5fb58da098f902607f,
title = "N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: A study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects",
abstract = "This study investigated the clinical and neuropsychological correlates of N-acetyl aspartate (NAA) concentration in the anterior cingulate cortex (ACC) in schizophrenia, and explored whether ACC NAA concentration is sensitive to symptom change following cognitive behaviour therapy for psychosis (CBTp). Participants comprised 30 patients and 15 healthy controls who underwent magnetic resonance spectroscopy of the ACC and were assessed on frontal lobe based neuropsychological tasks. Twenty-four (of 30) patients were followed-up; 11 subsequently received 8-9 months of CBTp in addition to standard care (CBTp + SC) and 13 received SC only. At baseline (i) NAA and Cr concentrations were lower in patients compared to controls, (ii) in patients, NAA concentration correlated inversely with positive symptoms and general psychopathology (positive symptoms explained 21{\%} of the variance; total variance explained = 25{\%}) and Cho concentration correlated inversely with positive symptoms, and (iii) in controls, NAA concentration correlated positively with working and short-term memory and Cr concentration inversely with executive function. NAA concentration tended to increase in CBTp + SC patients at follow-up (n = 7 with usable data) concomitant with improvement in positive symptoms. NAA concentration may be more closely associated with symptoms and symptom change than frontal lobe based neuropsychological function in schizophrenia, perhaps because the latter is relatively stable during the long-term illness course.",
author = "Preethi Premkumar and Parbhakar, {Vivek A.} and Dominic Fannon and David Lythgoe and Steven Williams and Elizabeth Kuipers and Veena Kumari",
year = "2010",
month = "6",
day = "30",
doi = "10.1016/j.pscychresns.2010.02.008",
language = "English",
volume = "182",
pages = "251 -- 260",
journal = "Psychiatry Research. Neuroimaging",
issn = "0925-4927",
number = "3",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia

T2 - A study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects

AU - Premkumar, Preethi

AU - Parbhakar, Vivek A.

AU - Fannon, Dominic

AU - Lythgoe, David

AU - Williams, Steven

AU - Kuipers, Elizabeth

AU - Kumari, Veena

PY - 2010/6/30

Y1 - 2010/6/30

N2 - This study investigated the clinical and neuropsychological correlates of N-acetyl aspartate (NAA) concentration in the anterior cingulate cortex (ACC) in schizophrenia, and explored whether ACC NAA concentration is sensitive to symptom change following cognitive behaviour therapy for psychosis (CBTp). Participants comprised 30 patients and 15 healthy controls who underwent magnetic resonance spectroscopy of the ACC and were assessed on frontal lobe based neuropsychological tasks. Twenty-four (of 30) patients were followed-up; 11 subsequently received 8-9 months of CBTp in addition to standard care (CBTp + SC) and 13 received SC only. At baseline (i) NAA and Cr concentrations were lower in patients compared to controls, (ii) in patients, NAA concentration correlated inversely with positive symptoms and general psychopathology (positive symptoms explained 21% of the variance; total variance explained = 25%) and Cho concentration correlated inversely with positive symptoms, and (iii) in controls, NAA concentration correlated positively with working and short-term memory and Cr concentration inversely with executive function. NAA concentration tended to increase in CBTp + SC patients at follow-up (n = 7 with usable data) concomitant with improvement in positive symptoms. NAA concentration may be more closely associated with symptoms and symptom change than frontal lobe based neuropsychological function in schizophrenia, perhaps because the latter is relatively stable during the long-term illness course.

AB - This study investigated the clinical and neuropsychological correlates of N-acetyl aspartate (NAA) concentration in the anterior cingulate cortex (ACC) in schizophrenia, and explored whether ACC NAA concentration is sensitive to symptom change following cognitive behaviour therapy for psychosis (CBTp). Participants comprised 30 patients and 15 healthy controls who underwent magnetic resonance spectroscopy of the ACC and were assessed on frontal lobe based neuropsychological tasks. Twenty-four (of 30) patients were followed-up; 11 subsequently received 8-9 months of CBTp in addition to standard care (CBTp + SC) and 13 received SC only. At baseline (i) NAA and Cr concentrations were lower in patients compared to controls, (ii) in patients, NAA concentration correlated inversely with positive symptoms and general psychopathology (positive symptoms explained 21% of the variance; total variance explained = 25%) and Cho concentration correlated inversely with positive symptoms, and (iii) in controls, NAA concentration correlated positively with working and short-term memory and Cr concentration inversely with executive function. NAA concentration tended to increase in CBTp + SC patients at follow-up (n = 7 with usable data) concomitant with improvement in positive symptoms. NAA concentration may be more closely associated with symptoms and symptom change than frontal lobe based neuropsychological function in schizophrenia, perhaps because the latter is relatively stable during the long-term illness course.

U2 - 10.1016/j.pscychresns.2010.02.008

DO - 10.1016/j.pscychresns.2010.02.008

M3 - Article

VL - 182

SP - 251

EP - 260

JO - Psychiatry Research. Neuroimaging

JF - Psychiatry Research. Neuroimaging

SN - 0925-4927

IS - 3

ER -

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