NADPH oxidase signaling and cardiac myocyte function

Ashwin Akki; Min Zhang; Colin Murdoch; Alison Brewer; Ajay M. Shah

doi:10.1016/j.yjmcc.2009.04.004

NADPH oxidase signaling and cardiac myocyte function

Ashwin Akki, Min Zhang, Colin Murdoch, Alison Brewer, Ajay M. Shah

Cardiovascular Sciences

Research output: Contribution to journal › Review article › peer-review

109 Citations (Scopus)

Abstract

The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.

Original language	English
Pages (from-to)	15-22
Number of pages	8
Journal	Journal of Molecular and Cellular Cardiology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/j.yjmcc.2009.04.004
Publication status	Published - Jul 2009

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10.1016/j.yjmcc.2009.04.004

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title = "NADPH oxidase signaling and cardiac myocyte function",

abstract = "The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.",

author = "Ashwin Akki and Min Zhang and Colin Murdoch and Alison Brewer and Shah, {Ajay M.}",

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AU - Akki, Ashwin

AU - Zhang, Min

AU - Murdoch, Colin

AU - Brewer, Alison

AU - Shah, Ajay M.

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Y1 - 2009/7

N2 - The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.

AB - The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.

U2 - 10.1016/j.yjmcc.2009.04.004

DO - 10.1016/j.yjmcc.2009.04.004

M3 - Review article

SN - 1095-8584

VL - 47

SP - 15

EP - 22

JO - Journal of Molecular and Cellular Cardiology

JF - Journal of Molecular and Cellular Cardiology

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ER -

NADPH oxidase signaling and cardiac myocyte function

Abstract

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