NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies

TY - JOUR

T1 - NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies

AU - Sirker, Alexander

AU - Zhang, Min

AU - Shah, Ajay M.

PY - 2011/9

Y1 - 2011/9

N2 - NADPH oxidase family enzymes (or NOXs) are the major sources of reactive oxygen species (ROS) that are implicated in the pathophysiology of many cardiovascular diseases. These enzymes appear to be especially important in the modulation of redox-sensitive signalling pathways that underlie key cellular functions such as growth, differentiation, migration and proliferation. Seven distinct members of the family have been identified of which four (namely NOX1, 2, 4 and 5) may have cardiovascular functions. In this article, we review our current understanding of the roles of NOX enzymes in several common cardiovascular disease states, with a focus on data from genetic studies and clinical data where available.

AB - NADPH oxidase family enzymes (or NOXs) are the major sources of reactive oxygen species (ROS) that are implicated in the pathophysiology of many cardiovascular diseases. These enzymes appear to be especially important in the modulation of redox-sensitive signalling pathways that underlie key cellular functions such as growth, differentiation, migration and proliferation. Seven distinct members of the family have been identified of which four (namely NOX1, 2, 4 and 5) may have cardiovascular functions. In this article, we review our current understanding of the roles of NOX enzymes in several common cardiovascular disease states, with a focus on data from genetic studies and clinical data where available.

U2 - 10.1007/s00395-011-0190-z

DO - 10.1007/s00395-011-0190-z

M3 - Literature review

VL - 106

SP - 735

EP - 747

JO - Basic Research in Cardiology

JF - Basic Research in Cardiology

IS - 5

ER -