Naltrexone and lofexidine combination treatment compared with conventional lofexidine treatment for in-patient opiate detoxification

N Buntwal; J Bearn; M Gossop; J Strang

doi:10.1016/S0376-8716(99)00116-7

Naltrexone and lofexidine combination treatment compared with conventional lofexidine treatment for in-patient opiate detoxification

N Buntwal^*, J Bearn, M Gossop, J Strang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

This study compares a naltrexone/lofexidine combination treatment with a 7-day course of lofexidine alone in the treatment of opiate withdrawal in 22 opiate-dependent patients. Withdrawal symptoms were significantly less severe on days 4-7, and 9-13, in the naltrexone/lofexidine combination group. There were no significant differences in the percentage of patients completing detoxification or in the mean length of stay for the two groups. Both treatments had similar, minimal effects on blood pressure. The naltrexone/lofexidine combination was associated with a more rapid resolution of the opiate withdrawal syndrome than a 7-day lofexidine-only treatment schedule, without substantial increases in withdrawal symptoms or hypotensive side-effects.

Original language	English
Pages (from-to)	183-188
Number of pages	6
Journal	Drug and alcohol dependence
Volume	59
Issue number	2
DOIs	https://doi.org/10.1016/S0376-8716(99)00116-7
Publication status	Published - 1 May 2000

Keywords

lofexidine
naltrexone
opiate detoxification
OPIOID DETOXIFICATION
WITHDRAWAL SYMPTOMS
ABRUPT WITHDRAWAL
RANDOMIZED TRIAL
METHADONE
CLONIDINE
NALOXONE
INDUCTION
PROGRAMS
ADDICTS

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title = "Naltrexone and lofexidine combination treatment compared with conventional lofexidine treatment for in-patient opiate detoxification",

abstract = "This study compares a naltrexone/lofexidine combination treatment with a 7-day course of lofexidine alone in the treatment of opiate withdrawal in 22 opiate-dependent patients. Withdrawal symptoms were significantly less severe on days 4-7, and 9-13, in the naltrexone/lofexidine combination group. There were no significant differences in the percentage of patients completing detoxification or in the mean length of stay for the two groups. Both treatments had similar, minimal effects on blood pressure. The naltrexone/lofexidine combination was associated with a more rapid resolution of the opiate withdrawal syndrome than a 7-day lofexidine-only treatment schedule, without substantial increases in withdrawal symptoms or hypotensive side-effects. ",

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author = "N Buntwal and J Bearn and M Gossop and J Strang",

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doi = "10.1016/S0376-8716(99)00116-7",

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T1 - Naltrexone and lofexidine combination treatment compared with conventional lofexidine treatment for in-patient opiate detoxification

AU - Buntwal, N

AU - Bearn, J

AU - Gossop, M

AU - Strang, J

PY - 2000/5/1

Y1 - 2000/5/1

N2 - This study compares a naltrexone/lofexidine combination treatment with a 7-day course of lofexidine alone in the treatment of opiate withdrawal in 22 opiate-dependent patients. Withdrawal symptoms were significantly less severe on days 4-7, and 9-13, in the naltrexone/lofexidine combination group. There were no significant differences in the percentage of patients completing detoxification or in the mean length of stay for the two groups. Both treatments had similar, minimal effects on blood pressure. The naltrexone/lofexidine combination was associated with a more rapid resolution of the opiate withdrawal syndrome than a 7-day lofexidine-only treatment schedule, without substantial increases in withdrawal symptoms or hypotensive side-effects.

AB - This study compares a naltrexone/lofexidine combination treatment with a 7-day course of lofexidine alone in the treatment of opiate withdrawal in 22 opiate-dependent patients. Withdrawal symptoms were significantly less severe on days 4-7, and 9-13, in the naltrexone/lofexidine combination group. There were no significant differences in the percentage of patients completing detoxification or in the mean length of stay for the two groups. Both treatments had similar, minimal effects on blood pressure. The naltrexone/lofexidine combination was associated with a more rapid resolution of the opiate withdrawal syndrome than a 7-day lofexidine-only treatment schedule, without substantial increases in withdrawal symptoms or hypotensive side-effects.

KW - lofexidine

KW - naltrexone

KW - opiate detoxification

KW - OPIOID DETOXIFICATION

KW - WITHDRAWAL SYMPTOMS

KW - ABRUPT WITHDRAWAL

KW - RANDOMIZED TRIAL

KW - METHADONE

KW - CLONIDINE

KW - NALOXONE

KW - INDUCTION

KW - PROGRAMS

KW - ADDICTS

U2 - 10.1016/S0376-8716(99)00116-7

DO - 10.1016/S0376-8716(99)00116-7

M3 - Article

SN - 0376-8716

VL - 59

SP - 183

EP - 188

JO - Drug and alcohol dependence

JF - Drug and alcohol dependence

IS - 2

ER -

Naltrexone and lofexidine combination treatment compared with conventional lofexidine treatment for in-patient opiate detoxification

Abstract

Keywords

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