Nanocapsule designs for antimicrobial resistance

Irene Marzuoli, Carlos H.B. Cruz, Christian D. Lorenz, Franca Fraternali*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The pressing need of new antimicrobial products is growing stronger, particularly because of widespread antimicrobial resistance, endangering our ability to treat common infections. The recent coronavirus pandemic has dramatically highlighted the necessity of effective antibacterial and antiviral protection. This work explores at the molecular level the mechanism of action of antibacterial nanocapsules assembled in virus-like particles, their stability and their interaction with mammal and antimicrobial model membranes. We use Molecular Dynamics with force-fields of different granularity and protein design strategies to study the stability, self-assembly and membrane poration properties of these nanocapsules.

Original languageEnglish
Pages (from-to)10342-10355
Number of pages14
JournalNanoscale
Volume13
Issue number23
Early online date2021
DOIs
Publication statusPublished - 21 Jun 2021

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