Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery

Salman Ahmad Mustfa; Eleonora Maurizi; John McGrath; Ciro Chiappini

doi:10.1002/adtp.202000160

Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery

Salman Ahmad Mustfa, Eleonora Maurizi, John McGrath, Ciro Chiappini^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

Topical treatments have been widely adopted to address a broad range of conditions across multiple sites thanks to their convenience, versatility, and effectiveness. While bypassing systemic biobarriers and avoiding systemic side effects by delivering directly to the target tissue, topical treatments still face significant local biobarriers that limit their efficacy. The toolset available for nanodelivery systems and their inherent multifunctionality can contribute to simultaneously address otherwise intractable challenges related to barrier function evasion, drug solubility, bioavailability, pharmacokinetics, smart and sustained release, quantitative co-delivery, and local targeting which are key to successful topical treatments. This review summarizes the outstanding challenges associated with the topical treatments of key diseases of the skin, mucosae, eyes, and ears, and highlights how nanodelivery systems are being developed to address them effectively.

Original language	English
Article number	2000160
Journal	Advanced Therapeutics
Volume	4
Issue number	1
DOIs	https://doi.org/10.1002/adtp.202000160
Publication status	Published - Jan 2021

Keywords

biobarriers
drug delivery
nanomedicines
topical delivery

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10.1002/adtp.202000160

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title = "Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery",

abstract = "Topical treatments have been widely adopted to address a broad range of conditions across multiple sites thanks to their convenience, versatility, and effectiveness. While bypassing systemic biobarriers and avoiding systemic side effects by delivering directly to the target tissue, topical treatments still face significant local biobarriers that limit their efficacy. The toolset available for nanodelivery systems and their inherent multifunctionality can contribute to simultaneously address otherwise intractable challenges related to barrier function evasion, drug solubility, bioavailability, pharmacokinetics, smart and sustained release, quantitative co-delivery, and local targeting which are key to successful topical treatments. This review summarizes the outstanding challenges associated with the topical treatments of key diseases of the skin, mucosae, eyes, and ears, and highlights how nanodelivery systems are being developed to address them effectively.",

keywords = "biobarriers, drug delivery, nanomedicines, topical delivery",

author = "Mustfa, {Salman Ahmad} and Eleonora Maurizi and John McGrath and Ciro Chiappini",

note = "Funding Information: S.M., J.M.G. and C.C. acknowledge support from CureEB through the ?Nanocol? grant. C.C. acknowledges support from the European Research Council through the ?EnBioN? grant and the Royal Society through the ?Genepattern? grant. Publisher Copyright: {\textcopyright} 2020 The Authors. Published by Wiley-VCH GmbH Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jan,

doi = "10.1002/adtp.202000160",

language = "English",

volume = "4",

journal = "Advanced Therapeutics",

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AU - Mustfa, Salman Ahmad

AU - Maurizi, Eleonora

AU - McGrath, John

AU - Chiappini, Ciro

N1 - Funding Information: S.M., J.M.G. and C.C. acknowledge support from CureEB through the ?Nanocol? grant. C.C. acknowledges support from the European Research Council through the ?EnBioN? grant and the Royal Society through the ?Genepattern? grant. Publisher Copyright: © 2020 The Authors. Published by Wiley-VCH GmbH Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1

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N2 - Topical treatments have been widely adopted to address a broad range of conditions across multiple sites thanks to their convenience, versatility, and effectiveness. While bypassing systemic biobarriers and avoiding systemic side effects by delivering directly to the target tissue, topical treatments still face significant local biobarriers that limit their efficacy. The toolset available for nanodelivery systems and their inherent multifunctionality can contribute to simultaneously address otherwise intractable challenges related to barrier function evasion, drug solubility, bioavailability, pharmacokinetics, smart and sustained release, quantitative co-delivery, and local targeting which are key to successful topical treatments. This review summarizes the outstanding challenges associated with the topical treatments of key diseases of the skin, mucosae, eyes, and ears, and highlights how nanodelivery systems are being developed to address them effectively.

AB - Topical treatments have been widely adopted to address a broad range of conditions across multiple sites thanks to their convenience, versatility, and effectiveness. While bypassing systemic biobarriers and avoiding systemic side effects by delivering directly to the target tissue, topical treatments still face significant local biobarriers that limit their efficacy. The toolset available for nanodelivery systems and their inherent multifunctionality can contribute to simultaneously address otherwise intractable challenges related to barrier function evasion, drug solubility, bioavailability, pharmacokinetics, smart and sustained release, quantitative co-delivery, and local targeting which are key to successful topical treatments. This review summarizes the outstanding challenges associated with the topical treatments of key diseases of the skin, mucosae, eyes, and ears, and highlights how nanodelivery systems are being developed to address them effectively.

KW - biobarriers

KW - drug delivery

KW - nanomedicines

KW - topical delivery

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Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery

Abstract

Keywords

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