King's College London

Research portal

Nanoparticle modification in biological media: implications for oral nanomedicines

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)40487-40497
Number of pages11
JournalRSC Advances
Volume9
Issue number69
Early online date6 Dec 2019
DOIs
Accepted/In press28 Nov 2019
E-pub ahead of print6 Dec 2019
PublishedDec 2019

Documents

King's Authors

Abstract

Nanomedicine has shown potential in enabling oral administration of poorly absorbable drugs, such as biologics. As part of the process related to optimisation of the safety and efficacy of nanomedicines, it is imperative that the interaction of nanoparticles with the biological systems - including the gut – is fully characterised. In this article, we provide an overview of the major mechanisms by which nanoparticles may transform upon introduction in biological media. Specifically, the phenomena of association, dissolution and biomolecule adsorption are discussed, together with factors which influence the occurrence of each phenomenon. The implications of these phenomena within the context of therapeutic action of nanomedicines, which includes reduced targeting efficiency, are also explored. Finally, we will comment on nanoparticle modification within the gut environment, including the currently available gastrointestinal models for the study of nano-bio interactions, with implications in the area of nanomedicines for oral administration.

Download statistics

No data available

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454