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National surveillance data analysis of COVID-19 vaccine uptake in England by women of reproductive age

Research output: Contribution to journalArticlepeer-review

Laura Magee, Erika Molteni, Vicky Bowyer, Jeffrey Bone, Harriet Boulding, Asma Khalil, Hiten Mistry, Lucilla Poston, Sergio A. Silverio, Ingrid Wolfe, Emma Duncan, Peter von Dadelszen, and the RESILIENT Study Group

Original languageEnglish
Article number956
Pages (from-to)1-8
JournalNature Communications
Issue number1
Early online date22 Feb 2023
Accepted/In press16 Jan 2023
E-pub ahead of print22 Feb 2023
PublishedDec 2023

Bibliographical note

Funding Information: This project was funded by the National Institute for Health Research (NIHR) HSDR Programme [Project reference number NIHR134293, CI: L.A.M., Co-I: H.B., E.D., P.v.D., A.K., L.P., S.A.S., and I.W.]. Publisher Copyright: © 2023, The Author(s).


King's Authors


Women of reproductive age are a group of particular concern with regards to vaccine uptake, related to their unique considerations of menstruation, fertility, and pregnancy. To obtain vaccine uptake data specific to this group, we obtained vaccine surveillance data from the Office for National Statistics, linked with COVID-19 vaccination status from the National Immunisation Management Service, England, from 8 Dec 2020 to 15 Feb 2021; data from 13,128,525 such women at population-level, were clustered by age (18–29, 30–39, and 40–49 years), self-defined ethnicity (19 UK government categories), and index of multiple deprivation (IMD, geographically-defined IMD quintiles). Here we show that among women of reproductive age, older age, White ethnicity and being in the least-deprived index of multiple deprivation are each independently associated with higher vaccine uptake, for first and second doses; however, ethnicity exerts the strongest influence (and IMD the weakest). These findings should inform future vaccination public messaging and policy.

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