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Native mass spectrometry goes more native: Investigation of membrane protein complexes directly from SMALPs

Research output: Contribution to journalArticle

Nils Hellwig, Oliver Peetz, Zainab Ahdash, Igor Tascón, Paula J. Booth, Vedrana Mikusevic, Marina Diskowski, Argyris Politis, Yvonne Hellmich, Inga Hänelt, Eamonn Reading, Nina Morgner

Original languageEnglish
Pages (from-to)13702-13705
Number of pages4
JournalChemical communications (Cambridge, England)
Issue number97
Early online date19 Nov 2018
Accepted/In press6 Sep 2018
E-pub ahead of print19 Nov 2018


King's Authors


Other than more widely used methods, the use of styrene maleic acid allows the direct extraction of membrane proteins from the lipid bilayer into SMALPs keeping it in its native lipid surrounding. Here we present the combined use of SMALPs and LILBID-MS, allowing determination of oligomeric states of membrane proteins of different functionality directly from the native nanodiscs.

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