Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors

Araz Ahmed; Alessandro Gulino; Simita Amayo; Walter Arancio; Ada Maria Florena; Beatrice Belmonte; Abdo Jurjus; Angelo Leone; Isabelle Miletich

doi:10.1007/s10735-019-09849-5

Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors

Araz Ahmed, Alessandro Gulino, Simita Amayo, Walter Arancio, Ada Maria Florena, Beatrice Belmonte, Abdo Jurjus, Angelo Leone^*, Isabelle Miletich

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression.

Original language	English
Journal	JOURNAL OF MOLECULAR HISTOLOGY
DOIs	https://doi.org/10.1007/s10735-019-09849-5
Publication status	Published - 1 Jan 2019

Keywords

Atrial natriuretic peptide, ANP
Autonomic nervous system
B-type natriuretic peptide, BNP
C-type natriuretic peptide, CNP
Natriuretic peptide receptor A, NPRA
Natriuretic peptide receptor B, NPRB
Natriuretic peptide receptor C, NPRC
Oral squamous cell carcinoma
Salivary gland
Submandibular gland

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10735-019-09849-5

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title = "Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors",

abstract = "The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression.",

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author = "Araz Ahmed and Alessandro Gulino and Simita Amayo and Walter Arancio and Florena, {Ada Maria} and Beatrice Belmonte and Abdo Jurjus and Angelo Leone and Isabelle Miletich",

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doi = "10.1007/s10735-019-09849-5",

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T1 - Natriuretic peptide system expression in murine and human submandibular salivary glands

T2 - a study of the spatial localisation of ANB, BNP, CNP and their receptors

AU - Ahmed, Araz

AU - Gulino, Alessandro

AU - Amayo, Simita

AU - Arancio, Walter

AU - Florena, Ada Maria

AU - Belmonte, Beatrice

AU - Jurjus, Abdo

AU - Leone, Angelo

AU - Miletich, Isabelle

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression.

AB - The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression.

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KW - Autonomic nervous system

KW - B-type natriuretic peptide, BNP

KW - C-type natriuretic peptide, CNP

KW - Natriuretic peptide receptor A, NPRA

KW - Natriuretic peptide receptor B, NPRB

KW - Natriuretic peptide receptor C, NPRC

KW - Oral squamous cell carcinoma

KW - Salivary gland

KW - Submandibular gland

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AN - SCOPUS:85075041731

SN - 1567-2379

JO - JOURNAL OF MOLECULAR HISTOLOGY

JF - JOURNAL OF MOLECULAR HISTOLOGY

ER -

Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors

Abstract

Keywords

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