TY - JOUR
T1 - Natural course of health and well-being in non-hospitalised children and young people after testing for SARS-CoV-2
T2 - a prospective follow-up study over 12 months
AU - Pinto Pereira, Snehal M.
AU - Shafran, Roz
AU - Nugawela, Manjula D.
AU - Panagi, Laura
AU - Hargreaves, Dougal
AU - Ladhani, Shamez N.
AU - Bennett, Sophie D.
AU - Chalder, Trudie
AU - Dalrymple, Emma
AU - Ford, Tamsin
AU - Heyman, Isobel
AU - McOwat, Kelsey
AU - Rojas, Natalia K.
AU - Sharma, Kishan
AU - Simmons, Ruth
AU - White, Simon R.
AU - Stephenson, Terence
N1 - Funding Information:
NIHR/UKRI (ref: COVLT0022).The Department of Health and Social Care, as the National Institute for Health Research (NIHR), and UK Research & Innovation (UKRI) awarded grant COVLT0022 but were not involved in study design, data collection, analysis, interpretation or writing.Terence Stephenson is Chair of the Health Research Authority and therefore recused himself from the Research Ethics Application. Trudie Chalder is a member of the National Institute for Health and Care Excellence committee for long COVID. She has written self-help books on chronic fatigue and has done workshops on chronic fatigue and post infectious syndromes. Dougal Hargreaves had a part-time secondment as Deputy Chief Scientific Adviser from September 2020 to September 2021, whereby his salary for 2 days per week was paid by the Department for Education (England) to Imperial College London. Sophie Bennett and Roz Shafran are both part of Great Ormond Street Hospital NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health, where their research is made possible by the National Institute of Health Research (NIHR) Great Ormond Street Hospital Biomedical Research Centre. Sophie Bennett and Roz Shafran are co-authors on a book published in August 2020, titled Oxford Guide to Brief and Low Intensity Interventions for Children and Young People.Michael Lattimore, UKHSA, as Project Officer for the CLoCk study. Olivia Swann and Elizabeth Whittaker designed the elements of the ISARIC Paediatric COVID-19 follow-up questionnaire which were incorporated into the online questionnaire used in this study to which all the CLoCk Consortium members contributed. Lana Fox-Smith and Jake Dudley supported the formatting of the manuscript and references. This work is independent research jointly funded by the National Institute for Health and Care Research (NIHR) and UK Research & Innovation (UKRI) who have awarded funding grant number COVLT0022. All research at Great Ormond Street Hospital Charity NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR Great Ormond Street Hospital Biomedical Research Centre. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR, UKRI or the Department of Health and Social Care. SMPP is supported by a UK Medical Research Council Career Development Award (ref: MR/P020372/1). DH is supported by the NIHR through the Applied Research Collaboration (ARC) North-West London and the School of Public Health Research. SRW is supported by the UKRI Medical Research Council (MC_UU_00002/2) and the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014).
Funding Information:
This work is independent research jointly funded by the National Institute for Health and Care Research (NIHR) and UK Research & Innovation (UKRI) who have awarded funding grant number COVLT0022. All research at Great Ormond Street Hospital Charity NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR Great Ormond Street Hospital Biomedical Research Centre . The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR, UKRI or the Department of Health and Social Care. SMPP is supported by a UK Medical Research Council Career Development Award (ref: MR/P020372/1 ). DH is supported by the NIHR through the Applied Research Collaboration ( ARC ) North-West London and the School of Public Health Research. SRW is supported by the UKRI Medical Research Council ( MC_UU_00002/2 ) and the NIHR Cambridge Biomedical Research Centre ( BRC-1215-20014 ).
Publisher Copyright:
© 2022 The Author(s)
PY - 2023/2
Y1 - 2023/2
N2 - Background: Despite high numbers of children and young people (CYP) having acute COVID, there has been no prospective follow-up of CYP to establish the pattern of health and well-being over a year following infection. Methods: A non-hospitalised, national sample of 5086 (2909 SARS-COV-2 Positive; 2177 SARS-COV-2 Negative at baseline) CYP aged 11–17 completed questionnaires 6- and 12-months after PCR-tests between October 2020 and March 2021 confirming SARS-CoV-2 infection (excluding CYP with subsequent (re)infections). SARS-COV-2 Positive CYP was compared to age, sex and geographically-matched test-negative CYP. Findings: Ten of 21 symptoms had a prevalence less than 10% at baseline, 6- and 12-months post-test in both test-positives and test-negatives. Of the other 11 symptoms, in test-positives who had these at baseline, the prevalence of all symptoms declined greatly by 12-months. For CYP first describing one of these at 6-months, there was a decline in prevalence by 12-months. The overall prevalence of 9 of 11 symptoms declined by 12-months. As many CYP first described shortness of breath and tiredness at either 6- or 12-months, the overall prevalence of these two symptoms in test-positives appeared to increase by 6-months and increase further by 12-months. However, within-individual examination demonstrated that the prevalence of shortness of breath and tiredness actually declined in those first describing these two symptoms at either baseline or 6-months. This pattern was also evident for these two symptoms in test-negatives. Similar patterns were observed for validated measures of poor quality of life, emotional and behavioural difficulties, poor well-being and fatigue. Moreover, broadly similar patterns and results were noted for the sub-sample (N = 1808) that had data at baseline, 3-, 6- and 12-months post-test. Interpretation: In CYP, the prevalence of adverse symptoms reported at the time of a positive PCR-test declined over 12-months. Some test-positives and test-negatives reported adverse symptoms for the first time at six- and 12-months post-test, particularly tiredness, shortness of breath, poor quality of life, poor well-being and fatigue suggesting they are likely to be caused by multiple factors. Funding: NIHR/ UKRI (ref: COVLT0022).
AB - Background: Despite high numbers of children and young people (CYP) having acute COVID, there has been no prospective follow-up of CYP to establish the pattern of health and well-being over a year following infection. Methods: A non-hospitalised, national sample of 5086 (2909 SARS-COV-2 Positive; 2177 SARS-COV-2 Negative at baseline) CYP aged 11–17 completed questionnaires 6- and 12-months after PCR-tests between October 2020 and March 2021 confirming SARS-CoV-2 infection (excluding CYP with subsequent (re)infections). SARS-COV-2 Positive CYP was compared to age, sex and geographically-matched test-negative CYP. Findings: Ten of 21 symptoms had a prevalence less than 10% at baseline, 6- and 12-months post-test in both test-positives and test-negatives. Of the other 11 symptoms, in test-positives who had these at baseline, the prevalence of all symptoms declined greatly by 12-months. For CYP first describing one of these at 6-months, there was a decline in prevalence by 12-months. The overall prevalence of 9 of 11 symptoms declined by 12-months. As many CYP first described shortness of breath and tiredness at either 6- or 12-months, the overall prevalence of these two symptoms in test-positives appeared to increase by 6-months and increase further by 12-months. However, within-individual examination demonstrated that the prevalence of shortness of breath and tiredness actually declined in those first describing these two symptoms at either baseline or 6-months. This pattern was also evident for these two symptoms in test-negatives. Similar patterns were observed for validated measures of poor quality of life, emotional and behavioural difficulties, poor well-being and fatigue. Moreover, broadly similar patterns and results were noted for the sub-sample (N = 1808) that had data at baseline, 3-, 6- and 12-months post-test. Interpretation: In CYP, the prevalence of adverse symptoms reported at the time of a positive PCR-test declined over 12-months. Some test-positives and test-negatives reported adverse symptoms for the first time at six- and 12-months post-test, particularly tiredness, shortness of breath, poor quality of life, poor well-being and fatigue suggesting they are likely to be caused by multiple factors. Funding: NIHR/ UKRI (ref: COVLT0022).
KW - Children and young people
KW - Long COVID
KW - Longitudinal
KW - Symptoms
KW - Well-being
UR - http://www.scopus.com/inward/record.url?scp=85146556109&partnerID=8YFLogxK
U2 - 10.1016/j.lanepe.2022.100554
DO - 10.1016/j.lanepe.2022.100554
M3 - Article
AN - SCOPUS:85146556109
SN - 2666-7762
VL - 25
JO - The Lancet Regional Health - Europe
JF - The Lancet Regional Health - Europe
M1 - 100554
ER -
