Abstract
Background and aims: Limited data are available on the long-term natural history of post-stroke depression. We aim to determine the prevalence, incidence, cumulative incidence, duration, persistent and recurrent rates of depression up to 24 years after stroke.
Methods: Data were from first-ever stroke patients registered in the South London Stroke Register. The Hospital Anxiety and Depression scale was used to assess patients for depression symptoms. Depression was defined as a cut-off score >7. Inverse probability weighting was used to deal with missing data.
Results: The prevalence of depression was stable at approximately 30% at any time up to 15 years after stroke, with a slight increase to 40% from 15-year onwards. Cumulative incidence of depression was 60%. Over 50% of patients had their first episodes within 1 year after stroke and about 90% within 5 years after stroke. 47% of the patients with depression at 3 months had recovered at 1 year. New onset and persistent depression were less common in later years, with recurrent cases comprising the largest proportion of depressed patients from 5-year onwards. Prevalence was higher in patients with severe physical disability, severe stroke, pre-stroke depression or cognitive impairment (40% vs 30%).
Conclusions: PSD featured had early onset, short duration and high recurrence, with recurrent depression comprising the greatest proportion of patients after 5 years. The prevalence of PSD was 10% higher in patients with defined risk factors. More medical resource should be allocated to those who ever depressed in monitoring recurrence in the long term.
Methods: Data were from first-ever stroke patients registered in the South London Stroke Register. The Hospital Anxiety and Depression scale was used to assess patients for depression symptoms. Depression was defined as a cut-off score >7. Inverse probability weighting was used to deal with missing data.
Results: The prevalence of depression was stable at approximately 30% at any time up to 15 years after stroke, with a slight increase to 40% from 15-year onwards. Cumulative incidence of depression was 60%. Over 50% of patients had their first episodes within 1 year after stroke and about 90% within 5 years after stroke. 47% of the patients with depression at 3 months had recovered at 1 year. New onset and persistent depression were less common in later years, with recurrent cases comprising the largest proportion of depressed patients from 5-year onwards. Prevalence was higher in patients with severe physical disability, severe stroke, pre-stroke depression or cognitive impairment (40% vs 30%).
Conclusions: PSD featured had early onset, short duration and high recurrence, with recurrent depression comprising the greatest proportion of patients after 5 years. The prevalence of PSD was 10% higher in patients with defined risk factors. More medical resource should be allocated to those who ever depressed in monitoring recurrence in the long term.
| Original language | English |
|---|---|
| Article number | 928 |
| Pages (from-to) | 341-341 |
| Journal | European Stroke Journal |
| Volume | 8 |
| Issue number | 2_suppl |
| DOIs | |
| Publication status | Published - 24 May 2023 |