Nectin and nectin-like molecules as markers, actors and targets in cancer

Translated title of the contribution: Nectin and nectin-like molecules as markers, actors and targets in cancer

Gaelle Fournier, Sarah Garrido-Urbani, Nicolas Reymond, Marc Lopez

Research output: Contribution to journalLiterature reviewpeer-review

14 Citations (Scopus)

Abstract

Nectin and nectin-like molecules as markers, actors and targets in cancer Nectin and nectin-like (necl) proteins form a family of 9 adhesion molecules that belong to the immunoglobulin superfamily. They play a key role in different biological processes such as cell polarity, proliferation, differentiation and migration in epithelial, endothelial, immune and nervous systems. Besides their role in physiology, they have been involved in different pathological processes in humans. They serve as virus receptors (poliovirus and herpes simplex virus), they are involved in orofacial malformation (CLPED1) and recently they have been described as markers, actors and potential therapeutics targets in cancer. Among them, necl-5, nectin-2 and nectin-4 are overexpressed in tumors, and are associated with a poor prognosis. On the opposite, necl-1, necl-2 and necl-4 act as tumor suppressors and are repressed in cancer. The involvement of nectins and necls molecules in cancer and their potential used in therapy is discussed in this review.
Translated title of the contributionNectin and nectin-like molecules as markers, actors and targets in cancer
Original languageFrench
Pages (from-to)273 - 279
Number of pages7
JournalM S-MEDECINE SCIENCES
Volume26
Issue number3
Publication statusPublished - Mar 2010

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