Neonatal liver failure: aetiologies and management—state of the art

Naresh P. Shanmugam; Sanjay Bansal; Anne Greenough; Anita Verma; Anil Dhawan

doi:10.1007/s00431-010-1309-1

Neonatal liver failure: aetiologies and management—state of the art

Naresh P. Shanmugam, Sanjay Bansal, Anne Greenough, Anita Verma, Anil Dhawan^*

^*Corresponding author for this work

King's College London

King's College Hospital

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Acute liver failure in neonates is rare, but carries a high mortality. Neonatal liver failure can be defined as "failure of the synthetic function of liver within 4 weeks of birth". Encephalopathy is not essential for the diagnosis. Acute liver failure in neonates differs from children with regard to aetiology and outcome. Common causes of neonatal liver failure are neonatal hemochromatosis, haematological malignancies, viral infections and liver-based metabolic defects. Early diagnosis and referral to a paediatric liver centre is recommended as liver transplantation is the only definitive treatment when supportive or a disease-specific treatment fails.

Original language	English
Pages (from-to)	573-581
Number of pages	9
Journal	European Journal of Pediatrics
Volume	170
Issue number	5
DOIs	https://doi.org/10.1007/s00431-010-1309-1
Publication status	Published - May 2011

Keywords

Neonatal liver failure
Acute liver failure
Liver transplantation
Hepatocyte transplantation
Neonatal hemochromatosis
Haemophagocytic lymphohistiocytosis
Mitochondrial disorders
FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
SIMPLEX-VIRUS-INFECTIONS
TYROSINEMIA TYPE-I
FULMINANT-HEPATITIS
HEMOCHROMATOSIS
TRANSPLANTATION
DISEASE
BACTERIAL
IMMUNOGLOBULIN
GALACTOSEMIA

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title = "Neonatal liver failure: aetiologies and management—state of the art",

abstract = "Acute liver failure in neonates is rare, but carries a high mortality. Neonatal liver failure can be defined as {"}failure of the synthetic function of liver within 4 weeks of birth{"}. Encephalopathy is not essential for the diagnosis. Acute liver failure in neonates differs from children with regard to aetiology and outcome. Common causes of neonatal liver failure are neonatal hemochromatosis, haematological malignancies, viral infections and liver-based metabolic defects. Early diagnosis and referral to a paediatric liver centre is recommended as liver transplantation is the only definitive treatment when supportive or a disease-specific treatment fails.",

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author = "Shanmugam, {Naresh P.} and Sanjay Bansal and Anne Greenough and Anita Verma and Anil Dhawan",

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doi = "10.1007/s00431-010-1309-1",

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T2 - aetiologies and management—state of the art

AU - Shanmugam, Naresh P.

AU - Bansal, Sanjay

AU - Greenough, Anne

AU - Verma, Anita

AU - Dhawan, Anil

PY - 2011/5

Y1 - 2011/5

N2 - Acute liver failure in neonates is rare, but carries a high mortality. Neonatal liver failure can be defined as "failure of the synthetic function of liver within 4 weeks of birth". Encephalopathy is not essential for the diagnosis. Acute liver failure in neonates differs from children with regard to aetiology and outcome. Common causes of neonatal liver failure are neonatal hemochromatosis, haematological malignancies, viral infections and liver-based metabolic defects. Early diagnosis and referral to a paediatric liver centre is recommended as liver transplantation is the only definitive treatment when supportive or a disease-specific treatment fails.

AB - Acute liver failure in neonates is rare, but carries a high mortality. Neonatal liver failure can be defined as "failure of the synthetic function of liver within 4 weeks of birth". Encephalopathy is not essential for the diagnosis. Acute liver failure in neonates differs from children with regard to aetiology and outcome. Common causes of neonatal liver failure are neonatal hemochromatosis, haematological malignancies, viral infections and liver-based metabolic defects. Early diagnosis and referral to a paediatric liver centre is recommended as liver transplantation is the only definitive treatment when supportive or a disease-specific treatment fails.

KW - Neonatal liver failure

KW - Acute liver failure

KW - Liver transplantation

KW - Hepatocyte transplantation

KW - Neonatal hemochromatosis

KW - Haemophagocytic lymphohistiocytosis

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KW - FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS

KW - SIMPLEX-VIRUS-INFECTIONS

KW - TYROSINEMIA TYPE-I

KW - FULMINANT-HEPATITIS

KW - HEMOCHROMATOSIS

KW - TRANSPLANTATION

KW - DISEASE

KW - BACTERIAL

KW - IMMUNOGLOBULIN

KW - GALACTOSEMIA

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EP - 581

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

IS - 5

ER -

Neonatal liver failure: aetiologies and management—state of the art

Abstract

Keywords

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