Neonatal Thrombocytopenia and Platelet Transfusion - A UK Perspective

Robert Carr; Anne M. Kelly; Lorna M. Williamson

doi:10.1159/000365163

Neonatal Thrombocytopenia and Platelet Transfusion - A UK Perspective

Robert Carr^*, Anne M. Kelly, Lorna M. Williamson

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

28 Citations (Scopus)

Abstract

Five percent of newborn infants admitted to UK neonatal units during a recent study developed a platelet count <60 × 109/l, and 60% of these were transfused platelets. This review summarises the common causes and mechanisms of thrombocytopenia in the newborn. Relevant evidence relating the platelet count to the risk of haemorrhage is reviewed, and current UK guidance on transfusion thresholds outlined. The UK policy for the provision of platelets for transfusion to neonates is described, including the particular requirements for neonatal allo-immune thrombocytopenia. Finally, we look towards the future and prospects for reducing the need to expose newborns to donor-derived platelets.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Neonatology
Volume	107
Issue number	1
DOIs	https://doi.org/10.1159/000365163
Publication status	Published - 2015

Keywords

Infant
Newborn
Platelet transfusion
Thrombocytopenia
FETOMATERNAL ALLOIMMUNE THROMBOCYTOPENIA
RANDOMIZED CONTROLLED-TRIAL
INTENSIVE-CARE-UNIT
AUTOIMMUNE THROMBOCYTOPENIA
PREMATURE-INFANTS
MANAGEMENT
PRETERM
THROMBOPOIETIN
PROPHYLAXIS
MULTICENTER

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title = "Neonatal Thrombocytopenia and Platelet Transfusion - A UK Perspective",

abstract = "Five percent of newborn infants admitted to UK neonatal units during a recent study developed a platelet count <60 × 109/l, and 60% of these were transfused platelets. This review summarises the common causes and mechanisms of thrombocytopenia in the newborn. Relevant evidence relating the platelet count to the risk of haemorrhage is reviewed, and current UK guidance on transfusion thresholds outlined. The UK policy for the provision of platelets for transfusion to neonates is described, including the particular requirements for neonatal allo-immune thrombocytopenia. Finally, we look towards the future and prospects for reducing the need to expose newborns to donor-derived platelets.",

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author = "Robert Carr and Kelly, {Anne M.} and Williamson, {Lorna M.}",

year = "2015",

doi = "10.1159/000365163",

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T1 - Neonatal Thrombocytopenia and Platelet Transfusion - A UK Perspective

AU - Carr, Robert

AU - Kelly, Anne M.

AU - Williamson, Lorna M.

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N2 - Five percent of newborn infants admitted to UK neonatal units during a recent study developed a platelet count <60 × 109/l, and 60% of these were transfused platelets. This review summarises the common causes and mechanisms of thrombocytopenia in the newborn. Relevant evidence relating the platelet count to the risk of haemorrhage is reviewed, and current UK guidance on transfusion thresholds outlined. The UK policy for the provision of platelets for transfusion to neonates is described, including the particular requirements for neonatal allo-immune thrombocytopenia. Finally, we look towards the future and prospects for reducing the need to expose newborns to donor-derived platelets.

AB - Five percent of newborn infants admitted to UK neonatal units during a recent study developed a platelet count <60 × 109/l, and 60% of these were transfused platelets. This review summarises the common causes and mechanisms of thrombocytopenia in the newborn. Relevant evidence relating the platelet count to the risk of haemorrhage is reviewed, and current UK guidance on transfusion thresholds outlined. The UK policy for the provision of platelets for transfusion to neonates is described, including the particular requirements for neonatal allo-immune thrombocytopenia. Finally, we look towards the future and prospects for reducing the need to expose newborns to donor-derived platelets.

KW - Infant

KW - Newborn

KW - Platelet transfusion

KW - Thrombocytopenia

KW - FETOMATERNAL ALLOIMMUNE THROMBOCYTOPENIA

KW - RANDOMIZED CONTROLLED-TRIAL

KW - INTENSIVE-CARE-UNIT

KW - AUTOIMMUNE THROMBOCYTOPENIA

KW - PREMATURE-INFANTS

KW - MANAGEMENT

KW - PRETERM

KW - THROMBOPOIETIN

KW - PROPHYLAXIS

KW - MULTICENTER

U2 - 10.1159/000365163

DO - 10.1159/000365163

M3 - Literature review

SN - 1661-7800

VL - 107

SP - 1

EP - 7

JO - Neonatology

JF - Neonatology

IS - 1

ER -

Neonatal Thrombocytopenia and Platelet Transfusion - A UK Perspective

Abstract

Keywords

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