Neonatal white matter microstructure and emotional development during the preschool years in children who were born very preterm

TY - JOUR

T1 - Neonatal white matter microstructure and emotional development during the preschool years in children who were born very preterm

AU - Kanel, Dana

AU - Vanes, Lucy D.

AU - Pecheva, Diliana

AU - Hadaya, Laila

AU - Falconer, Shona

AU - Counsell, Serena J.

AU - Edwards, David A.

AU - Nosarti, Chiara

N1 - Funding Information: This work was supported by Medical Research Council (United Kingdom) Grants MR/K006355/1, MR/L011530/1, and MR/S026460/1; the Wellcome/ EPSRC Centre for Medical Engineering Grant WT 203148/Z/16/Z; the Biotechnology and Biological Sciences Research Council Grant BB/J014567/ 1; and the Action Medical Research and Dangoor Education Grant GN2606. This work uses data acquired during independent research funded by the National Institute for Health Research Programme Grants for Applied Research Programme (RP-PG-0707-10154). Publisher Copyright: © 2021 Kanel et al. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Children born very preterm (,33 weeks of gestation) are at a higher risk of developing socio-emotional difficulties compared with those born at term. In this longitudinal study, we tested the hypothesis that diffusion characteristics of white matter (WM) tracts implicated in socio-emotional processing assessed in the neonatal period are associated with socio-emotional development in 151 very preterm children previously enrolled into the Evaluation of Preterm Imaging study (EudraCT 2009-011602-42). All children underwent diffusion tensor imaging at term-equivalent age and fractional anisotropy (FA) was quantified in the uncinate fasciculus (UF), inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), and superior longitudinal fasciculus (SLF). Children’s socio-emotional development was evaluated at preschool age (median = 4.63 years). Exploratory factor analysis conducted on the outcome variables revealed a three-factor structure, with latent constructs summarized as: “emotion moderation,” “social function,” and “empathy.” Results of linear regression analyses, adjusting for full-scale IQ and clinical and socio-demographic variables, showed an association between lower FA in the right UF and higher “emotion moderation” scores (b = 0.280; p, 0.001), which was mainly driven by negative affectivity scores (b = 0.281; p = 0.001). Results further showed an association between higher full-scale IQ and better social functioning (b = 0.334, p, 0.001). Girls had higher empathy scores than boys (b = 0.341, p = 0.006). These findings suggest that early alterations of diffusion characteristics of the UF could represent a biological substrate underlying the link between very preterm birth and emotional dysregulation in childhood and beyond.

AB - Children born very preterm (,33 weeks of gestation) are at a higher risk of developing socio-emotional difficulties compared with those born at term. In this longitudinal study, we tested the hypothesis that diffusion characteristics of white matter (WM) tracts implicated in socio-emotional processing assessed in the neonatal period are associated with socio-emotional development in 151 very preterm children previously enrolled into the Evaluation of Preterm Imaging study (EudraCT 2009-011602-42). All children underwent diffusion tensor imaging at term-equivalent age and fractional anisotropy (FA) was quantified in the uncinate fasciculus (UF), inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), and superior longitudinal fasciculus (SLF). Children’s socio-emotional development was evaluated at preschool age (median = 4.63 years). Exploratory factor analysis conducted on the outcome variables revealed a three-factor structure, with latent constructs summarized as: “emotion moderation,” “social function,” and “empathy.” Results of linear regression analyses, adjusting for full-scale IQ and clinical and socio-demographic variables, showed an association between lower FA in the right UF and higher “emotion moderation” scores (b = 0.280; p, 0.001), which was mainly driven by negative affectivity scores (b = 0.281; p = 0.001). Results further showed an association between higher full-scale IQ and better social functioning (b = 0.334, p, 0.001). Girls had higher empathy scores than boys (b = 0.341, p = 0.006). These findings suggest that early alterations of diffusion characteristics of the UF could represent a biological substrate underlying the link between very preterm birth and emotional dysregulation in childhood and beyond.

KW - Diffusion MRI

KW - Preterm children

KW - Socio-emotional development

KW - Tractography

UR - http://www.scopus.com/inward/record.url?scp=85116020267&partnerID=8YFLogxK

U2 - 10.1523/ENEURO.0546-20.2021

DO - 10.1523/ENEURO.0546-20.2021

M3 - Article

C2 - 34373253

AN - SCOPUS:85116020267

SN - 2373-2822

VL - 8

JO - eNeuro

JF - eNeuro

IS - 5

M1 - ENEURO.0546-20.2021

ER -