Nerve Growth Factor and Pain Mechanisms

TY - JOUR

T1 - Nerve Growth Factor and Pain Mechanisms

AU - Denk, Franziska

AU - Bennett, David L.

AU - McMahon, Stephen B

PY - 2017

Y1 - 2017

N2 - Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology. We also discuss the surprising number of questions that remain about NGF expression patterns and NGF's various functions and interaction partners in relation to persistent pain and the potential side effects of anti-NGF therapy. Expected final online publication date for the Annual Review of Neuroscience Volume 40 is July 8, 2017. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

AB - Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology. We also discuss the surprising number of questions that remain about NGF expression patterns and NGF's various functions and interaction partners in relation to persistent pain and the potential side effects of anti-NGF therapy. Expected final online publication date for the Annual Review of Neuroscience Volume 40 is July 8, 2017. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

KW - Journal Article

UR - http://www.scopus.com/inward/record.url?scp=85027026364&partnerID=8YFLogxK

U2 - 10.1146/annurev-neuro-072116-031121

DO - 10.1146/annurev-neuro-072116-031121

M3 - Article

C2 - 28441116

SN - 0147-006X

VL - 40

SP - 307

EP - 325

JO - Annual Review of Neuroscience

JF - Annual Review of Neuroscience

ER -