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Nesprin-2 epsilon: A novel nesprin isoform expressed in human ovary and Ntera-2 cells

Research output: Contribution to journalArticlepeer-review

Le Thanh Lam, Sabrina V. Boehm, Roland G. Roberts, Glenn E. Morris

Original languageEnglish
Pages (from-to)291 - 295
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number2
Published26 Aug 2011

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  • King's College London


The nuclear envelope-associated cytoskeletal protein, nesprin-2, is encoded by a large gene containing several internal promoters that produce shorter isoforms. In a study of Ntera-2 teratocarcinoma cells, a novel isoform, nesprin-2-epsilon, was found to be the major mRNA and protein product of the nesprin-2 gene. Its existence was predicted by bioinformatic analysis, but this is the first direct demonstration of both the mRNA and the 120 kDa protein which is located at the nuclear envelope. In a panel of 21 adult and foetal human tissues, the nesprin-2-epsilon mRNA was strongly expressed in ovary but was a minor isoform elsewhere. The expression pattern suggests a possible link with very early development and a likely physiological role in ovary. (C) 2011 Elsevier Inc. All rights reserved.

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