TY - JOUR
T1 - Network-based atrophy modeling in the common epilepsies
T2 - A worldwide ENIGMA study
AU - ENIGMA
AU - Larivière, Sara
AU - Rodríguez-Cruces, Raúl
AU - Royer, Jessica
AU - Caligiuri, Maria Eugenia
AU - Gambardella, Antonio
AU - Concha, Luis
AU - Keller, Simon S.
AU - Cendes, Fernando
AU - Yasuda, Clarissa
AU - Bonilha, Leonardo
AU - Gleichgerrcht, Ezequiel
AU - Focke, Niels K.
AU - Domin, Martin
AU - von Podewills, Felix
AU - Langner, Soenke
AU - Rummel, Christian
AU - Wiest, Roland
AU - Martin, Pascal
AU - Kotikalapudi, Raviteja
AU - O'Brien, Terence J.
AU - Sinclair, Benjamin
AU - Vivash, Lucy
AU - Desmond, Patricia M.
AU - Alhusaini, Saud
AU - Doherty, Colin P.
AU - Cavalleri, Gianpiero L.
AU - Delanty, Norman
AU - Kälviäinen, Reetta
AU - Jackson, Graeme D.
AU - Kowalczyk, Magdalena
AU - Mascalchi, Mario
AU - Semmelroch, Mira
AU - Thomas, Rhys H.
AU - Soltanian-Zadeh, Hamid
AU - Davoodi-Bojd, Esmaeil
AU - Zhang, Junsong
AU - Lenge, Matteo
AU - Guerrini, Renzo
AU - Bartolini, Emanuele
AU - Hamandi, Khalid
AU - Foley, Sonya
AU - Weber, Bernd
AU - Depondt, Chantal
AU - Absil, Julie
AU - Carr, Sarah J.A.
AU - Abela, Eugenio
AU - Richardson, Mark P.
AU - Devinsky, Orrin
AU - Severino, Mariasavina
AU - Striano, Pasquale
PY - 2020/11/18
Y1 - 2020/11/18
N2 - Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.
AB - Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.
UR - http://www.scopus.com/inward/record.url?scp=85096408152&partnerID=8YFLogxK
U2 - 10.1126/sciadv.abc6457
DO - 10.1126/sciadv.abc6457
M3 - Article
C2 - 33208365
AN - SCOPUS:85096408152
SN - 2375-2548
VL - 6
JO - Science Advances
JF - Science Advances
IS - 47
M1 - eabc6457
ER -