Neural abnormalities during cognitive generation of affect in treatment-resistant depression.

V Kumari; Martina T. Mitterschiffthaler; John D. Teasdale; Gin S. Malhi; Richard G. Brown; Vincent Giampietro; Michael J. Brammer; Lucia Poon; Andrew Simmons; Steven C. R. Williams; Stuart A. Checkley; Tonmoy Sharma

doi:10.1016/S0006-3223(02)01785-7

Neural abnormalities during cognitive generation of affect in treatment-resistant depression.

V Kumari, Martina T. Mitterschiffthaler, John D. Teasdale, Gin S. Malhi, Richard G. Brown, Vincent Giampietro, Michael J. Brammer, Lucia Poon, Andrew Simmons, Steven C. R. Williams, Stuart A. Checkley, Tonmoy Sharma

Research output: Contribution to journal › Article › peer-review

145 Citations (Scopus)

Abstract

Background: Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness. Methods: Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression. Results: Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs. Conclusions: Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and non responsiveness to treatment in depression. (C) 2003 Society of Biological Psychiatry.

Original language	English
Pages (from-to)	777 - 791
Number of pages	15
Journal	Biological psychiatry
Volume	54
Issue number	8
DOIs	https://doi.org/10.1016/S0006-3223(02)01785-7
Publication status	Published - 15 Oct 2003

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Kumari, V., Mitterschiffthaler, M. T., Teasdale, J. D., Malhi, G. S., Brown, R. G., Giampietro, V., Brammer, M. J., Poon, L., Simmons, A., Williams, S. C. R., Checkley, S. A., & Sharma, T. (2003). Neural abnormalities during cognitive generation of affect in treatment-resistant depression. Biological psychiatry, 54(8), 777 - 791. https://doi.org/10.1016/S0006-3223(02)01785-7

@article{a8d44925feb54330937543f50ca2476e,

title = "Neural abnormalities during cognitive generation of affect in treatment-resistant depression.",

abstract = "Background: Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness. Methods: Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression. Results: Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs. Conclusions: Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and non responsiveness to treatment in depression. (C) 2003 Society of Biological Psychiatry.",

author = "V Kumari and Mitterschiffthaler, {Martina T.} and Teasdale, {John D.} and Malhi, {Gin S.} and Brown, {Richard G.} and Vincent Giampietro and Brammer, {Michael J.} and Lucia Poon and Andrew Simmons and Williams, {Steven C. R.} and Checkley, {Stuart A.} and Tonmoy Sharma",

year = "2003",

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doi = "10.1016/S0006-3223(02)01785-7",

language = "English",

volume = "54",

pages = "777 -- 791",

journal = "Biological psychiatry",

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T1 - Neural abnormalities during cognitive generation of affect in treatment-resistant depression.

AU - Kumari, V

AU - Mitterschiffthaler, Martina T.

AU - Teasdale, John D.

AU - Malhi, Gin S.

AU - Brown, Richard G.

AU - Giampietro, Vincent

AU - Brammer, Michael J.

AU - Poon, Lucia

AU - Simmons, Andrew

AU - Williams, Steven C. R.

AU - Checkley, Stuart A.

AU - Sharma, Tonmoy

PY - 2003/10/15

Y1 - 2003/10/15

N2 - Background: Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness. Methods: Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression. Results: Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs. Conclusions: Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and non responsiveness to treatment in depression. (C) 2003 Society of Biological Psychiatry.

AB - Background: Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness. Methods: Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression. Results: Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs. Conclusions: Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and non responsiveness to treatment in depression. (C) 2003 Society of Biological Psychiatry.

U2 - 10.1016/S0006-3223(02)01785-7

DO - 10.1016/S0006-3223(02)01785-7

M3 - Article

SN - 1873-2402

VL - 54

SP - 777

EP - 791

JO - Biological psychiatry

JF - Biological psychiatry

IS - 8

ER -

Neural abnormalities during cognitive generation of affect in treatment-resistant depression.

Abstract

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