Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition

Stefan J. Borgwardt; Paul Allen; Sagnik Bhattacharyya; Paolo Fusar-Poli; Jose A. Crippa; Marc L. Seal; Valter Fraccaro; Zerrin Atakan; Rocio Martin-Santos; Colin O'Carroll; Katya Rubia; Philip K. McGuire

doi:10.1016/j.biopsych.2008.05.011

Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition

Stefan J. Borgwardt, Paul Allen, Sagnik Bhattacharyya, Paolo Fusar-Poli, Jose A. Crippa, Marc L. Seal, Valter Fraccaro, Zerrin Atakan, Rocio Martin-Santos, Colin O'Carroll, Katya Rubia, Philip K. McGuire

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Abstract

Background: This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task.

Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design.

Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms.

Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

Original language	English
Pages (from-to)	966 - 973
Number of pages	8
Journal	Biological psychiatry
Volume	64
Issue number	11
DOIs	https://doi.org/10.1016/j.biopsych.2008.05.011
Publication status	Published - 1 Dec 2008

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Borgwardt, S. J., Allen, P., Bhattacharyya, S., Fusar-Poli, P., Crippa, J. A., Seal, M. L., Fraccaro, V., Atakan, Z., Martin-Santos, R., O'Carroll, C., Rubia, K., & McGuire, P. K. (2008). Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition. Biological psychiatry, 64(11), 966 - 973. https://doi.org/10.1016/j.biopsych.2008.05.011

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abstract = "Background: This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task.Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design.Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms.Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.",

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T1 - Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol

T2 - Effects During Response Inhibition

AU - Borgwardt, Stefan J.

AU - Allen, Paul

AU - Bhattacharyya, Sagnik

AU - Fusar-Poli, Paolo

AU - Crippa, Jose A.

AU - Seal, Marc L.

AU - Fraccaro, Valter

AU - Atakan, Zerrin

AU - Martin-Santos, Rocio

AU - O'Carroll, Colin

AU - Rubia, Katya

AU - McGuire, Philip K.

PY - 2008/12/1

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N2 - Background: This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task.Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design.Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms.Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

AB - Background: This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task.Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design.Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms.Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

U2 - 10.1016/j.biopsych.2008.05.011

DO - 10.1016/j.biopsych.2008.05.011

M3 - Article

SN - 1873-2402

VL - 64

SP - 966

EP - 973

JO - Biological psychiatry

JF - Biological psychiatry

IS - 11

ER -

Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition

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