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Neural circuit dysfunction in mouse models of neurodevelopmental disorders: Neurobiology of Disease

Research output: Contribution to journalArticle

Isabel del Pino, Beatriz Rico, Oscar Marín

Original languageEnglish
Pages (from-to)174-182
Number of pages9
JournalCURRENT OPINION IN NEUROBIOLOGY
Volume48
Early online date10 Jan 2018
DOIs
Publication statusPublished - Feb 2018

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Abstract

Neuropsychiatric disorders arise from the alteration of normal brain developmental trajectories disrupting the function of specific neuronal circuits. Recent advances in human genetics have greatly accelerated the identification of genes whose variation increases the susceptibility for neurodevelopmental disorders, most notably for autism spectrum disorder (ASD) and schizophrenia. In parallel, experimental studies in animal models — most typically in mice — are beginning to shed light on the role of these genes in the development and function of specific brain circuits. In spite of their limitations, understanding the impact of pathological gene variation in animal models at the level of specific neuronal populations and circuits will likely contribute to orienting human clinical studies in the search for precise disease mechanisms and novel treatments.

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