NEURAL CORRELATES OF AGE OF ONSET IN SCHIZOPHRENIA

M. Kyriakopoulos

NEURAL CORRELATES OF AGE OF ONSET IN SCHIZOPHRENIA

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference paper

Abstract

Schizophrenia is a neurodevelopmental disorder associated with structural brain abnormalities and compromised integration of cerebral function. Working memory, whose deficits are among the core cognitive abnormalities in schizophrenia, is subserved by fronto-parietal neural networks undergoing robust remodelling during adolescence. In this paper we discuss findings from our multi-modal neuroimaging studies including DTI in early-onset schizophrenia (EOS) and adult-onset schizophrenia, and functional MRI during a verbal working memory task in EOS. Our data are suggestive of a wide functional disintegration (without any compensatory hyperactivation within the networks involved in verbal working memory) early in the course of the illness, which may be more pronounced in EOS compared to adult-onset schizophrenia.

Original language	English
Title of host publication	PSYCHIATRY AND THE NEUROSCIENCES
Editors	CR Soldatos, DG Dikeos
Place of Publication	40128 BOLOGNA
Publisher	MEDIMOND S R L
Pages	151-154
Number of pages	4
ISBN (Print)	978-88-7587-618-0
Publication status	Published - 2011
Event	4th International Congress on Psychiatry and the Neurosciences - Thessaloniki, Greece Duration: 1 Nov 2010 → …

Conference

Conference	4th International Congress on Psychiatry and the Neurosciences
Country/Territory	Greece
City	Thessaloniki
Period	1/11/2010 → …

Keywords

WORKING-MEMORY
WHITE-MATTER
METAANALYSIS

Cite this

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title = "NEURAL CORRELATES OF AGE OF ONSET IN SCHIZOPHRENIA",

abstract = "Schizophrenia is a neurodevelopmental disorder associated with structural brain abnormalities and compromised integration of cerebral function. Working memory, whose deficits are among the core cognitive abnormalities in schizophrenia, is subserved by fronto-parietal neural networks undergoing robust remodelling during adolescence. In this paper we discuss findings from our multi-modal neuroimaging studies including DTI in early-onset schizophrenia (EOS) and adult-onset schizophrenia, and functional MRI during a verbal working memory task in EOS. Our data are suggestive of a wide functional disintegration (without any compensatory hyperactivation within the networks involved in verbal working memory) early in the course of the illness, which may be more pronounced in EOS compared to adult-onset schizophrenia.",

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AU - Kyriakopoulos, M.

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N2 - Schizophrenia is a neurodevelopmental disorder associated with structural brain abnormalities and compromised integration of cerebral function. Working memory, whose deficits are among the core cognitive abnormalities in schizophrenia, is subserved by fronto-parietal neural networks undergoing robust remodelling during adolescence. In this paper we discuss findings from our multi-modal neuroimaging studies including DTI in early-onset schizophrenia (EOS) and adult-onset schizophrenia, and functional MRI during a verbal working memory task in EOS. Our data are suggestive of a wide functional disintegration (without any compensatory hyperactivation within the networks involved in verbal working memory) early in the course of the illness, which may be more pronounced in EOS compared to adult-onset schizophrenia.

AB - Schizophrenia is a neurodevelopmental disorder associated with structural brain abnormalities and compromised integration of cerebral function. Working memory, whose deficits are among the core cognitive abnormalities in schizophrenia, is subserved by fronto-parietal neural networks undergoing robust remodelling during adolescence. In this paper we discuss findings from our multi-modal neuroimaging studies including DTI in early-onset schizophrenia (EOS) and adult-onset schizophrenia, and functional MRI during a verbal working memory task in EOS. Our data are suggestive of a wide functional disintegration (without any compensatory hyperactivation within the networks involved in verbal working memory) early in the course of the illness, which may be more pronounced in EOS compared to adult-onset schizophrenia.

KW - WORKING-MEMORY

KW - WHITE-MATTER

KW - METAANALYSIS

M3 - Conference paper

SN - 978-88-7587-618-0

SP - 151

EP - 154

BT - PSYCHIATRY AND THE NEUROSCIENCES

A2 - Soldatos, CR

A2 - Dikeos, DG

PB - MEDIMOND S R L

CY - 40128 BOLOGNA

T2 - 4th International Congress on Psychiatry and the Neurosciences

Y2 - 1 November 2010

ER -

NEURAL CORRELATES OF AGE OF ONSET IN SCHIZOPHRENIA

Abstract

Conference

Keywords

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