Neural correlates of executive function and working memory in the 'at-risk mental state'

TY - JOUR

T1 - Neural correlates of executive function and working memory in the 'at-risk mental state'

AU - Broome, Matthew R.

AU - Matthiasson, Pall

AU - Fusar-Poli, Paolo

AU - Woolley, James B.

AU - Johns, Louise C.

AU - Tabraham, Paul

AU - Bramon, Elvira

AU - Valmaggia, Lucia

AU - Williams, Steven C. R.

AU - Brammer, Michael J.

AU - Chitnis, Xavier

AU - McGuire, Philip K.

PY - 2009/1

Y1 - 2009/1

N2 - Background People with prodromal symptoms have a very high risk of developing psychosis. Aims To use functional magnetic resonance imaging to examine the neurocognitive basis of this Vulnerability. Method Cross-sectional comparison of regional activation in individuals with art 'at tisk mental state' (at-risk group: n=17), patients with first-episode schizophreniform psychosis (psychosis group: n=10) and healthy volunteers (controls: n=15) during an overt verbal fluency task and an N-back working memory task. Results A similar pattern of between-group differences in activation was evident across both tasks. Activation in the at-risk group was intermediate relative to that in controls and the psychosis group in the inferior frontal and anterior cingulate cortex during the verbal fluency task and in the inferior frontal, dorsolateral prefrontal and parietal cortex during the N-back task. Conclusions The at-risk mental state is associated with abnormalities of regional brain function that are qualitatively similar to, but less severe than, those in patients who have recently presented with psychosis.

AB - Background People with prodromal symptoms have a very high risk of developing psychosis. Aims To use functional magnetic resonance imaging to examine the neurocognitive basis of this Vulnerability. Method Cross-sectional comparison of regional activation in individuals with art 'at tisk mental state' (at-risk group: n=17), patients with first-episode schizophreniform psychosis (psychosis group: n=10) and healthy volunteers (controls: n=15) during an overt verbal fluency task and an N-back working memory task. Results A similar pattern of between-group differences in activation was evident across both tasks. Activation in the at-risk group was intermediate relative to that in controls and the psychosis group in the inferior frontal and anterior cingulate cortex during the verbal fluency task and in the inferior frontal, dorsolateral prefrontal and parietal cortex during the N-back task. Conclusions The at-risk mental state is associated with abnormalities of regional brain function that are qualitatively similar to, but less severe than, those in patients who have recently presented with psychosis.

U2 - 10.1192/bjp.bp.107.046789

DO - 10.1192/bjp.bp.107.046789

M3 - Article

SN - 1472-1465

VL - 194

SP - 25

EP - 33

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

IS - 1

M1 - N/A

ER -