Neural correlates of movement generation in the 'at-risk mental state'

TY - JOUR

T1 - Neural correlates of movement generation in the 'at-risk mental state'

AU - Broome, M. R.

AU - Matthiasson, P.

AU - Fusar-Poli, Paolo

AU - Woolley, J. B.

AU - Johns, L. C.

AU - Tabraham, P.

AU - Bramon, E.

AU - Valmaggia, L.

AU - Williams, S. C. R.

AU - Brammer, M. J.

AU - Chitnis, X.

AU - McGuire, P. K.

PY - 2010/10

Y1 - 2010/10

N2 - Objective:  People with ‘prodromal’ symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task.Method:  Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm.Results:  During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group.Conclusion:  The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe.

AB - Objective:  People with ‘prodromal’ symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task.Method:  Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm.Results:  During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group.Conclusion:  The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe.

U2 - 10.1111/j.1600-0447.2009.01524.x

DO - 10.1111/j.1600-0447.2009.01524.x

M3 - Article

SN - 1600-0447

VL - 122

SP - 295

EP - 301

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 4

ER -