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Neural correlates of reward in autism

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Neural correlates of reward in autism. / Schmitz, N; Rubia, K; Van Amelsvoort, T; Daly, E; Smith, A; Murphy, D G M.

In: British Journal of Psychiatry, Vol. 192, No. 1, 01.2008, p. 19 - 24.

Research output: Contribution to journalArticle

Harvard

Schmitz, N, Rubia, K, Van Amelsvoort, T, Daly, E, Smith, A & Murphy, DGM 2008, 'Neural correlates of reward in autism', British Journal of Psychiatry, vol. 192, no. 1, pp. 19 - 24. https://doi.org/10.1192/bjp.bp.107.036921

APA

Schmitz, N., Rubia, K., Van Amelsvoort, T., Daly, E., Smith, A., & Murphy, D. G. M. (2008). Neural correlates of reward in autism. British Journal of Psychiatry, 192(1), 19 - 24. https://doi.org/10.1192/bjp.bp.107.036921

Vancouver

Schmitz N, Rubia K, Van Amelsvoort T, Daly E, Smith A, Murphy DGM. Neural correlates of reward in autism. British Journal of Psychiatry. 2008 Jan;192(1):19 - 24. https://doi.org/10.1192/bjp.bp.107.036921

Author

Schmitz, N ; Rubia, K ; Van Amelsvoort, T ; Daly, E ; Smith, A ; Murphy, D G M. / Neural correlates of reward in autism. In: British Journal of Psychiatry. 2008 ; Vol. 192, No. 1. pp. 19 - 24.

Bibtex Download

@article{18a4b1cceceb4d679586def3bf2523d3,
title = "Neural correlates of reward in autism",
abstract = "BackgroundLack of social interaction, which is characteristically seen in people with autistic-spectrum disorder, may be caused by malfunctioning of the frontostriatal reward systems. However, no reported in vivo brain imaging studies have investigated reward mechanisms in autistic-spectrum disorder.AimsTo investigate functional brain activation during reward feedback in people with autistic-spectrum disorder and control individuals.MethodWe used event-related functional magnetic resonance imaging to examine the neural substrates of monetary reward in individuals with autistic-spectrum disorder and matched controls.ResultsWhen rewarded, individuals with autism compared with control individuals showed significantly greater brain activation in the left anterior cingulate gyrus. In addition, activation of this region was negatively correlated with social interaction as measured by the Autism Diagnostic Interview.ConclusionsIn people with autistic-spectrum disorder, achieving reward is associated with significant differences in the activation of areas known to be responsible for attention and arousal, and this may partially underpin some deficits in social behaviour.",
author = "N Schmitz and K Rubia and {Van Amelsvoort}, T and E Daly and A Smith and Murphy, {D G M}",
year = "2008",
month = "1",
doi = "10.1192/bjp.bp.107.036921",
language = "English",
volume = "192",
pages = "19 -- 24",
journal = "British Journal of Psychiatry",
issn = "0007-1250",
publisher = "Cambridge University Press",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Neural correlates of reward in autism

AU - Schmitz, N

AU - Rubia, K

AU - Van Amelsvoort, T

AU - Daly, E

AU - Smith, A

AU - Murphy, D G M

PY - 2008/1

Y1 - 2008/1

N2 - BackgroundLack of social interaction, which is characteristically seen in people with autistic-spectrum disorder, may be caused by malfunctioning of the frontostriatal reward systems. However, no reported in vivo brain imaging studies have investigated reward mechanisms in autistic-spectrum disorder.AimsTo investigate functional brain activation during reward feedback in people with autistic-spectrum disorder and control individuals.MethodWe used event-related functional magnetic resonance imaging to examine the neural substrates of monetary reward in individuals with autistic-spectrum disorder and matched controls.ResultsWhen rewarded, individuals with autism compared with control individuals showed significantly greater brain activation in the left anterior cingulate gyrus. In addition, activation of this region was negatively correlated with social interaction as measured by the Autism Diagnostic Interview.ConclusionsIn people with autistic-spectrum disorder, achieving reward is associated with significant differences in the activation of areas known to be responsible for attention and arousal, and this may partially underpin some deficits in social behaviour.

AB - BackgroundLack of social interaction, which is characteristically seen in people with autistic-spectrum disorder, may be caused by malfunctioning of the frontostriatal reward systems. However, no reported in vivo brain imaging studies have investigated reward mechanisms in autistic-spectrum disorder.AimsTo investigate functional brain activation during reward feedback in people with autistic-spectrum disorder and control individuals.MethodWe used event-related functional magnetic resonance imaging to examine the neural substrates of monetary reward in individuals with autistic-spectrum disorder and matched controls.ResultsWhen rewarded, individuals with autism compared with control individuals showed significantly greater brain activation in the left anterior cingulate gyrus. In addition, activation of this region was negatively correlated with social interaction as measured by the Autism Diagnostic Interview.ConclusionsIn people with autistic-spectrum disorder, achieving reward is associated with significant differences in the activation of areas known to be responsible for attention and arousal, and this may partially underpin some deficits in social behaviour.

U2 - 10.1192/bjp.bp.107.036921

DO - 10.1192/bjp.bp.107.036921

M3 - Article

VL - 192

SP - 19

EP - 24

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - 1

ER -

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