Neural correlates of reward in autism

TY - JOUR

T1 - Neural correlates of reward in autism

AU - Schmitz, N

AU - Rubia, K

AU - Van Amelsvoort, T

AU - Daly, E

AU - Smith, A

AU - Murphy, D G M

PY - 2008/1

Y1 - 2008/1

N2 - Background Lack of social interaction, which is characteristically seen in people with autistic-spectrum disorder, may be caused by malfunctioning of the frontostriatal reward systems. However, no reported in vivo brain imaging studies have investigated reward mechanisms in autistic-spectrum disorder. Aims To investigate functional brain activation during reward feedback in people with autistic-spectrum disorder and control individuals. Method We used event-related functional magnetic resonance imaging to examine the neural substrates of monetary reward in individuals with autistic-spectrum disorder and matched controls. Results When rewarded, individuals with autism compared with control individuals showed significantly greater brain activation in the left anterior cingulate gyrus. In addition, activation of this region was negatively correlated with social interaction as measured by the Autism Diagnostic Interview. Conclusions In people with autistic-spectrum disorder, achieving reward is associated with significant differences in the activation of areas known to be responsible for attention and arousal, and this may partially underpin some deficits in social behaviour.

AB - Background Lack of social interaction, which is characteristically seen in people with autistic-spectrum disorder, may be caused by malfunctioning of the frontostriatal reward systems. However, no reported in vivo brain imaging studies have investigated reward mechanisms in autistic-spectrum disorder. Aims To investigate functional brain activation during reward feedback in people with autistic-spectrum disorder and control individuals. Method We used event-related functional magnetic resonance imaging to examine the neural substrates of monetary reward in individuals with autistic-spectrum disorder and matched controls. Results When rewarded, individuals with autism compared with control individuals showed significantly greater brain activation in the left anterior cingulate gyrus. In addition, activation of this region was negatively correlated with social interaction as measured by the Autism Diagnostic Interview. Conclusions In people with autistic-spectrum disorder, achieving reward is associated with significant differences in the activation of areas known to be responsible for attention and arousal, and this may partially underpin some deficits in social behaviour.

U2 - 10.1192/bjp.bp.107.036921

DO - 10.1192/bjp.bp.107.036921

M3 - Article

SN - 1472-1465

VL - 192

SP - 19

EP - 24

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

IS - 1

ER -