Neural profile of callous traits in children: a population-based neuroimaging study

Koen Bolhuis, Essi Viding, Ryan L Muetzel, Hannan El Marroun, Desana Kocevska, Tonya White, H Tiemeier, Charlotte Cecil

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
181 Downloads (Pure)

Abstract

Background: Callous traits during childhood, e.g. lack of remorse and shallow affect, are a key risk marker for antisocial behavior. Although callous traits have been found to associate with structural and functional brain alterations, evidence to date has been almost exclusively limited to small, high-risk samples of boys. Here, we characterized gray and white matter brain correlates of callous traits in over 2000 children from the general population.

Methods: Data on mother-reported callous traits and brain imaging were collected at age 10 years from the Generation R Study. Structural MRI was used to investigate brain morphology using volumetric indices and whole-brain analyses (n=2146); diffusion tensor imaging (DTI) was used to assess global and specific white matter microstructure (n=2059).

Results: Callous traits were associated with lower global brain (e.g. total brain) volumes as well as decreased cortical surface area in frontal and temporal regions. Global mean diffusivity was negatively associated with callous traits, suggesting higher white matter microstructural integrity in children with elevated callous traits. Multiple individual tracts contributed to this global association, including the uncinate and cingulum. While no sex differences were observed for global volumetric indices, white matter associations were present only in girls .

Conclusions: This is the first study to provide a systematic characterization of the structural neural profile of callous traits in the general pediatric population. These findings extend previous work based on selected samples by demonstrating that childhood callous traits in the general population are characterized by widespread macro- and microstructural differences across the brain.
Original languageEnglish
JournalBiological psychiatry
Early online date29 Oct 2018
DOIs
Publication statusE-pub ahead of print - 29 Oct 2018

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