Neural respiratory drive predicts long-term outcome following admission for exacerbation of COPD: A post hoc analysis

Maxime Patout*, Leonor Meira, Rebecca D'Cruz, Elodie Lhuillier, Georgios Kaltsakas, Gill Arbane, Eui Sik Suh, Nicholas Hart, Patrick Brian Murphy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Neural respiratory drive (NRD), as reflected by change in parasternal muscle electromyogram (EMGpara), predicts clinical deterioration and safe discharge in patients admitted to hospital with an acute exacerbation of COPD (AECOPD). The clinical utility of NRD to predict the long-term outcome of patients following hospital admission with an AECOPD is unknown. We undertook a post hoc analysis of a previously published prospective observational cohort study measuring NRD in 120 patients with AECOPD. Sixty-nine (57.5%) patients died during follow-up (median 3.6 years). Respiratory failure was the most common cause of death (n=29; 42%). In multivariate analysis, factors independently associated with an increased mortality included NRD (HR 2.14, 95% CI 1.29 to 3.54, p=0.003), age (HR 2.03, 95% CI 1.23 to 3.34, p=0.006), PaCO 2 at admission (HR 1.83, 95% CI 1.06 to 3.06, p=0.022) and long-term oxygen use (HR 2.98, 95% CI 1.47 to 6.03, p=0.002). NRD at hospital discharge could be measured in order to assess efficacy of interventions targeted to optimise COPD and reduce mortality following an AECOPD. Original clinicaltrial.gov number: NCT01361451

Original languageEnglish
JournalThorax
Volume74
Issue number9
DOIs
Publication statusPublished - 1 Sept 2019

Keywords

  • COPD exacerbations
  • respiratory measurement
  • respiratory muscles

Fingerprint

Dive into the research topics of 'Neural respiratory drive predicts long-term outcome following admission for exacerbation of COPD: A post hoc analysis'. Together they form a unique fingerprint.

Cite this