Neural signatures of autism

Martha D Kaiser; Caitlin M Hudac; Sarah Shultz; Su Mei Lee; Celeste H M Cheung; Allison M Berken; Ben Deen; Naomi B Pitskel; Daniel R Sugrue; Avery C Voos; Celine A Saulnier; Pamela Ventola; Julie M Wolf; Ami Klin; Brent C Vander Wyk; Kevin A Pelphrey

doi:10.1073/pnas.1010412107

Neural signatures of autism

Martha D Kaiser, Caitlin M Hudac, Sarah Shultz, Su Mei Lee, Celeste H M Cheung, Allison M Berken, Ben Deen, Naomi B Pitskel, Daniel R Sugrue, Avery C Voos, Celine A Saulnier, Pamela Ventola, Julie M Wolf, Ami Klin, Brent C Vander Wyk, Kevin A Pelphrey

Psychology

Yale University

Research output: Contribution to journal › Article › peer-review

278 Citations (Scopus)

Abstract

Functional magnetic resonance imaging of brain responses to biological motion in children with autism spectrum disorder (ASD), unaffected siblings (US) of children with ASD, and typically developing (TD) children has revealed three types of neural signatures: (i) state activity, related to the state of having ASD that characterizes the nature of disruption in brain circuitry; (ii) trait activity, reflecting shared areas of dysfunction in US and children with ASD, thereby providing a promising neuroendophenotype to facilitate efforts to bridge genomic complexity and disorder heterogeneity; and (iii) compensatory activity, unique to US, suggesting a neural system-level mechanism by which US might compensate for an increased genetic risk for developing ASD. The distinct brain responses to biological motion exhibited by TD children and US are striking given the identical behavioral profile of these two groups. These findings offer far-reaching implications for our understanding of the neural systems underlying autism.

Original language	English
Article number	N/A
Pages (from-to)	21223-21228
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	107
Issue number	49
DOIs	https://doi.org/10.1073/pnas.1010412107
Publication status	Published - 7 Dec 2010

Keywords

Autistic Disorder
Child
Child Development Disorders, Pervasive
Humans
Magnetic Resonance Imaging
Movement
Neurons
Siblings

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10.1073/pnas.1010412107

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Kaiser, M. D., Hudac, C. M., Shultz, S., Lee, S. M., Cheung, C. H. M., Berken, A. M., Deen, B., Pitskel, N. B., Sugrue, D. R., Voos, A. C., Saulnier, C. A., Ventola, P., Wolf, J. M., Klin, A., Vander Wyk, B. C., & Pelphrey, K. A. (2010). Neural signatures of autism. Proceedings of the National Academy of Sciences of the United States of America, 107(49), 21223-21228. Article N/A. https://doi.org/10.1073/pnas.1010412107

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abstract = "Functional magnetic resonance imaging of brain responses to biological motion in children with autism spectrum disorder (ASD), unaffected siblings (US) of children with ASD, and typically developing (TD) children has revealed three types of neural signatures: (i) state activity, related to the state of having ASD that characterizes the nature of disruption in brain circuitry; (ii) trait activity, reflecting shared areas of dysfunction in US and children with ASD, thereby providing a promising neuroendophenotype to facilitate efforts to bridge genomic complexity and disorder heterogeneity; and (iii) compensatory activity, unique to US, suggesting a neural system-level mechanism by which US might compensate for an increased genetic risk for developing ASD. The distinct brain responses to biological motion exhibited by TD children and US are striking given the identical behavioral profile of these two groups. These findings offer far-reaching implications for our understanding of the neural systems underlying autism.",

keywords = "Autistic Disorder, Child, Child Development Disorders, Pervasive, Humans, Magnetic Resonance Imaging, Movement, Neurons, Siblings",

author = "Kaiser, {Martha D} and Hudac, {Caitlin M} and Sarah Shultz and Lee, {Su Mei} and Cheung, {Celeste H M} and Berken, {Allison M} and Ben Deen and Pitskel, {Naomi B} and Sugrue, {Daniel R} and Voos, {Avery C} and Saulnier, {Celine A} and Pamela Ventola and Wolf, {Julie M} and Ami Klin and {Vander Wyk}, {Brent C} and Pelphrey, {Kevin A}",

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doi = "10.1073/pnas.1010412107",

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Kaiser, MD, Hudac, CM, Shultz, S, Lee, SM, Cheung, CHM, Berken, AM, Deen, B, Pitskel, NB, Sugrue, DR, Voos, AC, Saulnier, CA, Ventola, P, Wolf, JM, Klin, A, Vander Wyk, BC & Pelphrey, KA 2010, 'Neural signatures of autism', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 49, N/A, pp. 21223-21228. https://doi.org/10.1073/pnas.1010412107

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T1 - Neural signatures of autism

AU - Kaiser, Martha D

AU - Hudac, Caitlin M

AU - Shultz, Sarah

AU - Lee, Su Mei

AU - Cheung, Celeste H M

AU - Berken, Allison M

AU - Deen, Ben

AU - Pitskel, Naomi B

AU - Sugrue, Daniel R

AU - Voos, Avery C

AU - Saulnier, Celine A

AU - Ventola, Pamela

AU - Wolf, Julie M

AU - Klin, Ami

AU - Vander Wyk, Brent C

AU - Pelphrey, Kevin A

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AB - Functional magnetic resonance imaging of brain responses to biological motion in children with autism spectrum disorder (ASD), unaffected siblings (US) of children with ASD, and typically developing (TD) children has revealed three types of neural signatures: (i) state activity, related to the state of having ASD that characterizes the nature of disruption in brain circuitry; (ii) trait activity, reflecting shared areas of dysfunction in US and children with ASD, thereby providing a promising neuroendophenotype to facilitate efforts to bridge genomic complexity and disorder heterogeneity; and (iii) compensatory activity, unique to US, suggesting a neural system-level mechanism by which US might compensate for an increased genetic risk for developing ASD. The distinct brain responses to biological motion exhibited by TD children and US are striking given the identical behavioral profile of these two groups. These findings offer far-reaching implications for our understanding of the neural systems underlying autism.

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KW - Magnetic Resonance Imaging

KW - Movement

KW - Neurons

KW - Siblings

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DO - 10.1073/pnas.1010412107

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SN - 0027-8424

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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ER -

Neural signatures of autism

Abstract

Keywords

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