Neural tube derived signals and Fgf8 act antagonistically to specify eye versus mandibular arch muscles

G von Scheven, L E Alvares, R C Mootoosamy, S Dietrich

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Recent knockout experiments in the mouse generated amazing craniofacial skeletal muscle phenotypes. Yet none of the genes could be placed into a molecular network, because the programme to control the development of muscles in the head is not known. Here we show that antagonistic signals from the neural tube and the branchial arches specify extraocular versus branchiomeric muscles. Moreover, we identified Fgf8 as the branchial arch derived signal. However, this molecule has an additional function in supporting the proliferative state of myoblasts, suppressing their differentiation, while a further branchial arch derived signal, namely Bmp7, is an overall negative regulator of head myogenesis
Original languageEnglish
Pages (from-to)2731 - 2745
Number of pages15
JournalDevelopment (Cambridge): for advances in developmental biology and stem cells
Volume133
Issue number14
DOIs
Publication statusPublished - Jul 2006

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