Neurally adjusted ventilatory assist (NAVA) in very prematurely born infants with evolving/ established BPD

Sandeep Shetty, Katie Evans, Peter Cornuaud, Anay Kulkarni, Donovan Duffy, Anne Greenough

Research output: Contribution to journalArticlepeer-review

65 Downloads (Pure)

Abstract

During neurally adjusted ventilatory assist (NAVA)/NIV (non-invasive) NAVA, a modified nasogastric feeding tube with electrodes monitors the electrical activity of the diaphragm (Edi). The Edi waveform determines the delivered pressure from the ventilator. Our objective was to determine whether NAVA/NIV-NAVA has advantages in infants with evolving/established bronchopulmonary dysplasia (BPD). Each infant who received NAVA/NIV-NAVA and conventional invasive and NIV was matched with two historical controls. Eighteen NAVA/NIV-NAVA infants median gestational age 25.3 (23.6-28.1) weeks were compared with 36 historical controls median gestational age 25.2 (23.1-29.1) weeks. Infants on NAVA/NIV-NAVA had lower extubation failure rates (median 0 (0-2) versus 1
(0-6) p=0.002), shorter durations of invasive ventilation (median 30.5 (1-90) days versus 40.5 (11-199) days p=0.046) and total duration of invasive and NIV to the point of discharge to the local hospital (median 80 (57-140) days versus 103.5 (60-246) days p=0.026). The overall LOS was lower in NAVA/NIV-NAVA group (111.5 (78-183) versus 140 days (82-266) days p=0.019). There were no significant differences in BPD [17/18 (94%) versus 32/36 (89%) p=0.511] or home oxygen rates (14/18 (78%) versus 23/36 (64%) p=0.305).
Conclusion: The combination of NAVA/NIV-NAVA compared to conventional invasive and non-invasive modes may be advantageous for preterm infants with evolving/established BPD.
Original languageEnglish
JournalAJP Reports
Publication statusPublished - 2021

Fingerprint

Dive into the research topics of 'Neurally adjusted ventilatory assist (NAVA) in very prematurely born infants with evolving/ established BPD'. Together they form a unique fingerprint.

Cite this