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Neuroanatomical and cognitive correlates of visual hallucinations in Parkinson's disease and dementia with Lewy bodies: Voxel-based morphometry and neuropsychological meta-analysis

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Stefania Pezzoli, Raquel Sánchez-Valle, Aleix Solanes, Matthew J. Kempton, Oliver Bandmann, Jae Il Shin, Annachiara Cagnin, Jennifer G. Goldman, Doug Merkitch, Michael J. Firbank, John Paul Taylor, Javier Pagonabarraga, Jaime Kulisevsky, Frederic Blanc, Norma Verdolini, Annalena Venneri, Joaquim Radua

Original languageEnglish
Pages (from-to)367-382
Number of pages16
JournalNeuroscience and Biobehavioral Reviews
Volume128
DOIs
PublishedSep 2021

Bibliographical note

Funding Information: The contribution of the Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) is acknowledged. SP was supported by a scholarship from the University of Sheffield and the Erasmus+program of the European Union . JR was supported by two grants from the Instituto de Salud Carlos III and co-funded by European Union (ERDF/ESF, ‘Investing in your future’): Miguel Servet Research Contract CPII19/00009 and Research Project Grants PI19/00394. MJF and J-PT were supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre (BRC) based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University . JP was funded by PERIS , Expedient Number SLT008/18/00088 ( Generalitat de Catalunya ); Rio Hortega CM17/00209, Instituto de Salud Carlos III (ISCIII), Spain; FIS grant PI18/01717 , Instituto de Salud Carlos III (ISCIII), Spain. Publisher Copyright: © 2021 Elsevier Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

Visual hallucinations (VH) are common in Parkinson's disease and dementia with Lewy bodies, two forms of Lewy body disease (LBD), but the neural substrates and mechanisms involved are still unclear. We conducted meta-analyses of voxel-based morphometry (VBM) and neuropsychological studies investigating the neuroanatomical and cognitive correlates of VH in LBD. For VBM (12 studies), we used Seed-based d Mapping with Permutation of Subject Images (SDM-PSI), including statistical parametric maps for 50% of the studies. For neuropsychology (35 studies), we used MetaNSUE to consider non-statistically significant unreported effects. VH were associated with smaller grey matter volume in occipital, frontal, occipitotemporal, and parietal areas (peak Hedges’ g -0.34 to -0.49). In patients with Parkinson's disease without dementia, VH were associated with lower verbal immediate memory performance (Hedges’ g -0.52). Both results survived correction for multiple comparisons. Abnormalities in these brain regions might reflect dysfunctions in brain networks sustaining visuoperceptive, attention, and executive abilities, with the latter also being at the basis of poor immediate memory performance.

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