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Neuroanatomy and neuropathology of autism spectrum disorder in humans

Research output: Chapter in Book/Report/Conference proceedingChapter

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Neuroanatomy and neuropathology of autism spectrum disorder in humans. / Ecker, Christine; Schmeisser, Michael J.; Loth, Eva; Murphy, Declan G.

Advances in Anatomy Embryology and Cell Biology. Vol. 224 Springer Verlag, 2017. p. 27-48 (Advances in Anatomy Embryology and Cell Biology; Vol. 224).

Research output: Chapter in Book/Report/Conference proceedingChapter

Harvard

Ecker, C, Schmeisser, MJ, Loth, E & Murphy, DG 2017, Neuroanatomy and neuropathology of autism spectrum disorder in humans. in Advances in Anatomy Embryology and Cell Biology. vol. 224, Advances in Anatomy Embryology and Cell Biology, vol. 224, Springer Verlag, pp. 27-48. https://doi.org/10.1007/978-3-319-52498-6_2

APA

Ecker, C., Schmeisser, M. J., Loth, E., & Murphy, D. G. (2017). Neuroanatomy and neuropathology of autism spectrum disorder in humans. In Advances in Anatomy Embryology and Cell Biology (Vol. 224, pp. 27-48). (Advances in Anatomy Embryology and Cell Biology; Vol. 224). Springer Verlag. https://doi.org/10.1007/978-3-319-52498-6_2

Vancouver

Ecker C, Schmeisser MJ, Loth E, Murphy DG. Neuroanatomy and neuropathology of autism spectrum disorder in humans. In Advances in Anatomy Embryology and Cell Biology. Vol. 224. Springer Verlag. 2017. p. 27-48. (Advances in Anatomy Embryology and Cell Biology). https://doi.org/10.1007/978-3-319-52498-6_2

Author

Ecker, Christine ; Schmeisser, Michael J. ; Loth, Eva ; Murphy, Declan G. / Neuroanatomy and neuropathology of autism spectrum disorder in humans. Advances in Anatomy Embryology and Cell Biology. Vol. 224 Springer Verlag, 2017. pp. 27-48 (Advances in Anatomy Embryology and Cell Biology).

Bibtex Download

@inbook{6c52eabb6745465bb4707c8a171e468c,
title = "Neuroanatomy and neuropathology of autism spectrum disorder in humans",
abstract = "Autism spectrum disorder (ASD) is a lifelong heterogeneous neurodevelopmental condition that is associated with differences in brain anatomy and connectivity. Yet, the molecular and cellular mechanisms that underpin the atypical developmental of the brain in ASD remain poorly understood. Here, we review the findings of in vivo neuroimaging studies examining the time course of atypical brain development in ASD and relate the different neurodevelopmental stages that are atypical in ASD to the known neurobiological mechanisms that drive the maturation of the typically developing brain. In particular, we focus on the notion of ‘early brain overgrowth’ in ASD, which may lead to differences in the formation of the brain’s micro- and macro-circuitry. Moreover, we attempt to link the in vivo reports describing differences in brain anatomy and connectivity on the macroscopic level to the increasing number of post-mortem studies examining the neural architecture of the brain in ASD on the microscopic level. In addition, we discuss future directions and outstanding questions in this particular field of research and highlight the need for establishing the link between micro- and macro-pathology in the same set of individuals with ASD based on advances in genetic, molecular and imaging techniques. In combination, these may proof to be invaluable for patient stratification and the development of novel pharmacotherapies in the future.",
author = "Christine Ecker and Schmeisser, {Michael J.} and Eva Loth and Murphy, {Declan G.}",
year = "2017",
doi = "10.1007/978-3-319-52498-6_2",
language = "English",
volume = "224",
series = "Advances in Anatomy Embryology and Cell Biology",
publisher = "Springer Verlag",
pages = "27--48",
booktitle = "Advances in Anatomy Embryology and Cell Biology",
address = "Germany",

}

RIS (suitable for import to EndNote) Download

TY - CHAP

T1 - Neuroanatomy and neuropathology of autism spectrum disorder in humans

AU - Ecker, Christine

AU - Schmeisser, Michael J.

AU - Loth, Eva

AU - Murphy, Declan G.

PY - 2017

Y1 - 2017

N2 - Autism spectrum disorder (ASD) is a lifelong heterogeneous neurodevelopmental condition that is associated with differences in brain anatomy and connectivity. Yet, the molecular and cellular mechanisms that underpin the atypical developmental of the brain in ASD remain poorly understood. Here, we review the findings of in vivo neuroimaging studies examining the time course of atypical brain development in ASD and relate the different neurodevelopmental stages that are atypical in ASD to the known neurobiological mechanisms that drive the maturation of the typically developing brain. In particular, we focus on the notion of ‘early brain overgrowth’ in ASD, which may lead to differences in the formation of the brain’s micro- and macro-circuitry. Moreover, we attempt to link the in vivo reports describing differences in brain anatomy and connectivity on the macroscopic level to the increasing number of post-mortem studies examining the neural architecture of the brain in ASD on the microscopic level. In addition, we discuss future directions and outstanding questions in this particular field of research and highlight the need for establishing the link between micro- and macro-pathology in the same set of individuals with ASD based on advances in genetic, molecular and imaging techniques. In combination, these may proof to be invaluable for patient stratification and the development of novel pharmacotherapies in the future.

AB - Autism spectrum disorder (ASD) is a lifelong heterogeneous neurodevelopmental condition that is associated with differences in brain anatomy and connectivity. Yet, the molecular and cellular mechanisms that underpin the atypical developmental of the brain in ASD remain poorly understood. Here, we review the findings of in vivo neuroimaging studies examining the time course of atypical brain development in ASD and relate the different neurodevelopmental stages that are atypical in ASD to the known neurobiological mechanisms that drive the maturation of the typically developing brain. In particular, we focus on the notion of ‘early brain overgrowth’ in ASD, which may lead to differences in the formation of the brain’s micro- and macro-circuitry. Moreover, we attempt to link the in vivo reports describing differences in brain anatomy and connectivity on the macroscopic level to the increasing number of post-mortem studies examining the neural architecture of the brain in ASD on the microscopic level. In addition, we discuss future directions and outstanding questions in this particular field of research and highlight the need for establishing the link between micro- and macro-pathology in the same set of individuals with ASD based on advances in genetic, molecular and imaging techniques. In combination, these may proof to be invaluable for patient stratification and the development of novel pharmacotherapies in the future.

UR - http://www.scopus.com/inward/record.url?scp=85020920938&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-52498-6_2

DO - 10.1007/978-3-319-52498-6_2

M3 - Chapter

AN - SCOPUS:85020920938

VL - 224

T3 - Advances in Anatomy Embryology and Cell Biology

SP - 27

EP - 48

BT - Advances in Anatomy Embryology and Cell Biology

PB - Springer Verlag

ER -

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