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Neuroanatomy of individual differences in language in adult males with autism

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Neuroanatomy of individual differences in language in adult males with autism. / Lai, Meng Chuan; Lombardo, Michael V.; Ecker, Christine; Chakrabarti, Bhismadev; Suckling, John; Bullmore, Edward T.; Happé, Francesca; Murphy, Declan G M; Baron-Cohen, Simon.

In: Cerebral Cortex, Vol. 25, No. 10, 01.10.2015, p. 3613-3628.

Research output: Contribution to journalArticle

Harvard

Lai, MC, Lombardo, MV, Ecker, C, Chakrabarti, B, Suckling, J, Bullmore, ET, Happé, F, Murphy, DGM & Baron-Cohen, S 2015, 'Neuroanatomy of individual differences in language in adult males with autism', Cerebral Cortex, vol. 25, no. 10, pp. 3613-3628. https://doi.org/10.1093/cercor/bhu211

APA

Lai, M. C., Lombardo, M. V., Ecker, C., Chakrabarti, B., Suckling, J., Bullmore, E. T., ... Baron-Cohen, S. (2015). Neuroanatomy of individual differences in language in adult males with autism. Cerebral Cortex, 25(10), 3613-3628. https://doi.org/10.1093/cercor/bhu211

Vancouver

Lai MC, Lombardo MV, Ecker C, Chakrabarti B, Suckling J, Bullmore ET et al. Neuroanatomy of individual differences in language in adult males with autism. Cerebral Cortex. 2015 Oct 1;25(10):3613-3628. https://doi.org/10.1093/cercor/bhu211

Author

Lai, Meng Chuan ; Lombardo, Michael V. ; Ecker, Christine ; Chakrabarti, Bhismadev ; Suckling, John ; Bullmore, Edward T. ; Happé, Francesca ; Murphy, Declan G M ; Baron-Cohen, Simon. / Neuroanatomy of individual differences in language in adult males with autism. In: Cerebral Cortex. 2015 ; Vol. 25, No. 10. pp. 3613-3628.

Bibtex Download

@article{3f5d07de3e2446d38edffd381e8e7150,
title = "Neuroanatomy of individual differences in language in adult males with autism",
abstract = "One potential source of heterogeneity within autism spectrum conditions (ASC) is language development and ability. In 80 high-functioning male adults with ASC, we tested if variations in developmental and current structural language are associated with current neuroanatomy. Groups with and without language delay differed behaviorally in early social reciprocity, current language, but not current autistic features. Language delay was associated with larger total gray matter (GM) volume, smaller relative volume at bilateral insula, ventral basal ganglia, and right superior, middle, and polar temporal structures, and larger relative volume at pons and medulla oblongata in adulthood. Despite this heterogeneity, those with and without language delay showed significant commonality in morphometric features when contrasted with matched neurotypical individuals (n=57). In ASC, better current language was associated with increased GM volume in bilateral temporal pole, superior temporal regions, dorsolateral fronto-parietal and cerebellar structures, and increased white matter volume in distributed frontal and insular regions. Furthermore, current language-neuroanatomy correlation patterns were similar across subgroups with or without language delay. High-functioning adult males with ASC show neuroanatomical variations associated with both developmental and current language characteristics. This underscores the importance of including both developmental and current language as specifiers for ASC, to help clarify heterogeneity.",
keywords = "Autism, Individual differences, Language, Neuroanatomy, Specifiers",
author = "Lai, {Meng Chuan} and Lombardo, {Michael V.} and Christine Ecker and Bhismadev Chakrabarti and John Suckling and Bullmore, {Edward T.} and Francesca Happ{\'e} and Murphy, {Declan G M} and Simon Baron-Cohen",
year = "2015",
month = "10",
day = "1",
doi = "10.1093/cercor/bhu211",
language = "English",
volume = "25",
pages = "3613--3628",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "10",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Neuroanatomy of individual differences in language in adult males with autism

AU - Lai, Meng Chuan

AU - Lombardo, Michael V.

AU - Ecker, Christine

AU - Chakrabarti, Bhismadev

AU - Suckling, John

AU - Bullmore, Edward T.

AU - Happé, Francesca

AU - Murphy, Declan G M

AU - Baron-Cohen, Simon

PY - 2015/10/1

Y1 - 2015/10/1

N2 - One potential source of heterogeneity within autism spectrum conditions (ASC) is language development and ability. In 80 high-functioning male adults with ASC, we tested if variations in developmental and current structural language are associated with current neuroanatomy. Groups with and without language delay differed behaviorally in early social reciprocity, current language, but not current autistic features. Language delay was associated with larger total gray matter (GM) volume, smaller relative volume at bilateral insula, ventral basal ganglia, and right superior, middle, and polar temporal structures, and larger relative volume at pons and medulla oblongata in adulthood. Despite this heterogeneity, those with and without language delay showed significant commonality in morphometric features when contrasted with matched neurotypical individuals (n=57). In ASC, better current language was associated with increased GM volume in bilateral temporal pole, superior temporal regions, dorsolateral fronto-parietal and cerebellar structures, and increased white matter volume in distributed frontal and insular regions. Furthermore, current language-neuroanatomy correlation patterns were similar across subgroups with or without language delay. High-functioning adult males with ASC show neuroanatomical variations associated with both developmental and current language characteristics. This underscores the importance of including both developmental and current language as specifiers for ASC, to help clarify heterogeneity.

AB - One potential source of heterogeneity within autism spectrum conditions (ASC) is language development and ability. In 80 high-functioning male adults with ASC, we tested if variations in developmental and current structural language are associated with current neuroanatomy. Groups with and without language delay differed behaviorally in early social reciprocity, current language, but not current autistic features. Language delay was associated with larger total gray matter (GM) volume, smaller relative volume at bilateral insula, ventral basal ganglia, and right superior, middle, and polar temporal structures, and larger relative volume at pons and medulla oblongata in adulthood. Despite this heterogeneity, those with and without language delay showed significant commonality in morphometric features when contrasted with matched neurotypical individuals (n=57). In ASC, better current language was associated with increased GM volume in bilateral temporal pole, superior temporal regions, dorsolateral fronto-parietal and cerebellar structures, and increased white matter volume in distributed frontal and insular regions. Furthermore, current language-neuroanatomy correlation patterns were similar across subgroups with or without language delay. High-functioning adult males with ASC show neuroanatomical variations associated with both developmental and current language characteristics. This underscores the importance of including both developmental and current language as specifiers for ASC, to help clarify heterogeneity.

KW - Autism

KW - Individual differences

KW - Language

KW - Neuroanatomy

KW - Specifiers

UR - http://www.scopus.com/inward/record.url?scp=84948699984&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhu211

DO - 10.1093/cercor/bhu211

M3 - Article

AN - SCOPUS:84948699984

VL - 25

SP - 3613

EP - 3628

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 10

ER -

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