Neuroanatomy of verbal working memory as a diagnostic biomarker for depression

Andre F Marquand; Janaina Mourão-Miranda; Michael J Brammer; Anthony J Cleare; Cynthia H Y Fu

doi:10.1097/WNR.0b013e328310425e

Neuroanatomy of verbal working memory as a diagnostic biomarker for depression

Andre F Marquand, Janaina Mourão-Miranda, Michael J Brammer, Anthony J Cleare, Cynthia H Y Fu

1Department of Hepatology, Imperial College London, London, UK. 2Institute of Liver Studies at King's College School of Medicine at King's College Hospital, London, UK. 3Institute of Human Health and Performance, University College London, London, UK. 4Department of Asthma Allergy and Lung Biology, King's College London, London, UK. 5Division of Critical Care Medicine, University of Alberta, Edmonton, Canada.

Research output: Contribution to journal › Article › peer-review

Abstract

The functional neuroanatomy of verbal working memory is a potential diagnostic biomarker for depression. Twenty patients with unipolar depression and 20 healthy controls performed a variable load version (n-back) of the task. Functional MRI data were analysed with support vector machine methods. Diagnostic classification was highest at the mid-level of task difficulty (2-back) (sensitivity 65%, specificity 70%, P<0.009). Significant classification of clinical response (>or=50% reduction in clinical symptom ratings) was found at the most difficult level (3-back) (sensitivity 85%, specificity 52%, P<0.003). The functional neuroanatomy of verbal working memory provides a statistically significant but clinically moderate contribution as a diagnostic biomarker for depression, whereas its potential as a neural predictor of clinical response requires further investigation.

Original language	English
Pages (from-to)	1507-11
Number of pages	5
Journal	Neuroreport
Volume	19
Issue number	15
DOIs	https://doi.org/10.1097/WNR.0b013e328310425e
Publication status	Published - 8 Oct 2008

Keywords

Adult
Brain/anatomy & histology
Cerebral Cortex/anatomy & histology
Depressive Disorder/diagnosis
Female
Frontal Lobe/anatomy & histology
Humans
Image Processing, Computer-Assisted/methods
Magnetic Resonance Imaging/methods
Male
Memory/physiology
Middle Aged
Neuroanatomy
Prefrontal Cortex/anatomy & histology
Psychiatric Status Rating Scales
Psychomotor Performance/physiology
Verbal Learning/physiology

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10.1097/WNR.0b013e328310425e

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title = "Neuroanatomy of verbal working memory as a diagnostic biomarker for depression",

abstract = "The functional neuroanatomy of verbal working memory is a potential diagnostic biomarker for depression. Twenty patients with unipolar depression and 20 healthy controls performed a variable load version (n-back) of the task. Functional MRI data were analysed with support vector machine methods. Diagnostic classification was highest at the mid-level of task difficulty (2-back) (sensitivity 65%, specificity 70%, P<0.009). Significant classification of clinical response (>or=50% reduction in clinical symptom ratings) was found at the most difficult level (3-back) (sensitivity 85%, specificity 52%, P<0.003). The functional neuroanatomy of verbal working memory provides a statistically significant but clinically moderate contribution as a diagnostic biomarker for depression, whereas its potential as a neural predictor of clinical response requires further investigation.",

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AU - Mourão-Miranda, Janaina

AU - Brammer, Michael J

AU - Cleare, Anthony J

AU - Fu, Cynthia H Y

PY - 2008/10/8

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N2 - The functional neuroanatomy of verbal working memory is a potential diagnostic biomarker for depression. Twenty patients with unipolar depression and 20 healthy controls performed a variable load version (n-back) of the task. Functional MRI data were analysed with support vector machine methods. Diagnostic classification was highest at the mid-level of task difficulty (2-back) (sensitivity 65%, specificity 70%, P<0.009). Significant classification of clinical response (>or=50% reduction in clinical symptom ratings) was found at the most difficult level (3-back) (sensitivity 85%, specificity 52%, P<0.003). The functional neuroanatomy of verbal working memory provides a statistically significant but clinically moderate contribution as a diagnostic biomarker for depression, whereas its potential as a neural predictor of clinical response requires further investigation.

AB - The functional neuroanatomy of verbal working memory is a potential diagnostic biomarker for depression. Twenty patients with unipolar depression and 20 healthy controls performed a variable load version (n-back) of the task. Functional MRI data were analysed with support vector machine methods. Diagnostic classification was highest at the mid-level of task difficulty (2-back) (sensitivity 65%, specificity 70%, P<0.009). Significant classification of clinical response (>or=50% reduction in clinical symptom ratings) was found at the most difficult level (3-back) (sensitivity 85%, specificity 52%, P<0.003). The functional neuroanatomy of verbal working memory provides a statistically significant but clinically moderate contribution as a diagnostic biomarker for depression, whereas its potential as a neural predictor of clinical response requires further investigation.

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KW - Magnetic Resonance Imaging/methods

KW - Male

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KW - Middle Aged

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KW - Prefrontal Cortex/anatomy & histology

KW - Psychiatric Status Rating Scales

KW - Psychomotor Performance/physiology

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ER -

Neuroanatomy of verbal working memory as a diagnostic biomarker for depression

Abstract

Keywords

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