Neurobehavioural characterisation and stratification of reinforcement-related behaviour

IMAGEN Consortium; Tianye Jia; Alex Ing; Erin Burke Quinlan; Nicole Tay; Qiang Luo; Biondo Francesca; Tobias Banaschewski; Gareth J Barker; Arun L W Bokde; Uli Bromberg; Christian Büchel; Sylvane Desrivières; Jianfeng Feng; Herta Flor; Antoine Grigis; Hugh Garavan; Penny Gowland; Andreas Heinz; Bernd Ittermann; Jean-Luc Martinot; Marie-Laure Paillère Martinot; Frauke Nees; Dimitri Papadopoulos Orfanos; Tomáš Paus; Luise Poustka; Juliane H Fröhner; Michael N Smolka; Henrik Walter; Robert Whelan; Gunter Schumann

doi:10.1038/s41562-020-0846-5

Neurobehavioural characterisation and stratification of reinforcement-related behaviour

IMAGEN Consortium, Tianye Jia, Alex Ing, Erin Burke Quinlan, Nicole Tay, Qiang Luo, Biondo Francesca, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Uli Bromberg, Christian Büchel, Sylvane Desrivières, Jianfeng Feng, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd IttermannJean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Gunter Schumann

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Abstract

Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.

Original language	English
Pages (from-to)	544-558
Number of pages	15
Journal	Nature Human Behaviour
Volume	4
Issue number	5
Early online date	20 Apr 2020
DOIs	https://doi.org/10.1038/s41562-020-0846-5
Publication status	Published - 1 May 2020

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IMAGEN Consortium, Jia, T., Ing, A., Quinlan, E. B., Tay, N., Luo, Q., Francesca, B., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Büchel, C., Desrivières, S., Feng, J., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., ... Schumann, G. (2020). Neurobehavioural characterisation and stratification of reinforcement-related behaviour. Nature Human Behaviour, 4(5), 544-558. https://doi.org/10.1038/s41562-020-0846-5

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title = "Neurobehavioural characterisation and stratification of reinforcement-related behaviour",

abstract = "Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.",

author = "{IMAGEN Consortium} and Tianye Jia and Alex Ing and Quinlan, {Erin Burke} and Nicole Tay and Qiang Luo and Biondo Francesca and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Sylvane Desrivi{\`e}res and Jianfeng Feng and Herta Flor and Antoine Grigis and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Gunter Schumann",

year = "2020",

month = may,

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doi = "10.1038/s41562-020-0846-5",

language = "English",

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IMAGEN Consortium, Jia, T , Ing, A , Quinlan, EB , Tay, N, Luo, Q, Francesca, B, Banaschewski, T, Barker, GJ, Bokde, ALW, Bromberg, U, Büchel, C, Desrivières, S, Feng, J, Flor, H, Grigis, A, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Martinot, M-LP, Nees, F, Orfanos, DP, Paus, T, Poustka, L, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R & Schumann, G 2020, 'Neurobehavioural characterisation and stratification of reinforcement-related behaviour', Nature Human Behaviour, vol. 4, no. 5, pp. 544-558. https://doi.org/10.1038/s41562-020-0846-5

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T1 - Neurobehavioural characterisation and stratification of reinforcement-related behaviour

AU - IMAGEN Consortium

AU - Jia, Tianye

AU - Ing, Alex

AU - Quinlan, Erin Burke

AU - Tay, Nicole

AU - Luo, Qiang

AU - Francesca, Biondo

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Desrivières, Sylvane

AU - Feng, Jianfeng

AU - Flor, Herta

AU - Grigis, Antoine

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

PY - 2020/5/1

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N2 - Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.

AB - Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.

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U2 - 10.1038/s41562-020-0846-5

DO - 10.1038/s41562-020-0846-5

M3 - Article

C2 - 32313235

SN - 2397-3374

VL - 4

SP - 544

EP - 558

JO - Nature Human Behaviour

JF - Nature Human Behaviour

IS - 5

ER -

Neurobehavioural characterisation and stratification of reinforcement-related behaviour

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