Neurobiological models of self-disorders in early schizophrenia

A. Mishara; I. Bonoldi; P. Allen; Grazia Rutigliano; J. Perez; P. Fusar-Poli; P. McGuire

doi:10.1093/schbul/sbv123

Neurobiological models of self-disorders in early schizophrenia

A. Mishara, I. Bonoldi^*, P. Allen, Grazia Rutigliano, J. Perez, P. Fusar-Poli, P. McGuire

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Self-disorders (SDs) (from the German Ichstörungen) are alterations of the first-person perspective, long associated with schizophrenia, particularly in early phases. Although psychopathological features of SDs continue to be studied, their neurobiological underpinnings are unknown. This makes it difficult to integrate SDs into contemporary models of psychosis. The present review aims to address this issue, starting from an historical excursus revealing an interconnection between neuroscientific models and the origin of the psychopathological concept of SDs. Subsequently, the more recent neurobiological models related to SDs are discussed, particularly with respect to the onset of schizophrenia.

Original language	English
Pages (from-to)	874-880
Number of pages	7
Journal	Schizophrenia Bulletin
Volume	42
Issue number	4
Early online date	18 Sept 2015
DOIs	https://doi.org/10.1093/schbul/sbv123
Publication status	Published - Jul 2016

Keywords

Aberrant salience
Bayesian modelling
Gruhle
Heidelberg mescaline study
Mayer-Gross
Neuroimaging
Phenomenology
Prodromal
Psychosis
Schizophrenia
Self-disorders

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/schbul/sbv123

Neurobiological models of self-disorders_MISHARA_Publishedonline18September2015_GREEN AAMAccepted author manuscript, 464 KB

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abstract = "Self-disorders (SDs) (from the German Ichst{\"o}rungen) are alterations of the first-person perspective, long associated with schizophrenia, particularly in early phases. Although psychopathological features of SDs continue to be studied, their neurobiological underpinnings are unknown. This makes it difficult to integrate SDs into contemporary models of psychosis. The present review aims to address this issue, starting from an historical excursus revealing an interconnection between neuroscientific models and the origin of the psychopathological concept of SDs. Subsequently, the more recent neurobiological models related to SDs are discussed, particularly with respect to the onset of schizophrenia.",

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AU - Bonoldi, I.

AU - Allen, P.

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AU - Perez, J.

AU - Fusar-Poli, P.

AU - McGuire, P.

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KW - Bayesian modelling

KW - Gruhle

KW - Heidelberg mescaline study

KW - Mayer-Gross

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KW - Phenomenology

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Neurobiological models of self-disorders in early schizophrenia

Abstract

Keywords

UN SDGs

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